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                                                                                1. CCRC-HaunerEN
                                                                                2. Clinical research
                                                                                3. Scivias Study

                                                                                Scivias Study

                                                                                • Aims of the Study:


                                                                                  • Identification of new biomarkers for the overall assessment of the systemic health status of childrenDevelopment of a novel diagnostic tool in children 
                                                                                  • Establishment of a normal range for fundus photography, OCT and OCT angiography with regard to retinal changes in various age groups

                                                                                  • Evaluation of the value of optical fundus evaluation in (early) diagnosis of a rare disease
                                                                                  • Establishing a reference range for changes in the transcriptome, metabolome and proteome in various age groups and in various acute and chronic diseases
                                                                                  • Correlation of systems biology data with disease activities of rare diseases
                                                                                  • Specification of phenotyping of patients within different disease groups

                                                                                • Scivias Study

                                                                                  Project Summary

                                                                                  Early detection of diseases is a central challenge for pediatric medicine. The earlier a disease is discovered, the easier it is to avoid complications and sequelae and to reduce long-term morbidity. This is particularly relevant for children with rare diseases in whom the diagnostic process is often delayed. Children with rare and chronic diseases are usually only diagnosed when their disease manifests or complications arise. Thus, there is an urgent need to develop and use new sensitive and specific diagnostic methods, preferably as non-invasive as possible.

                                                                                  Next generation sequencing technologies have revolutionized human genetics. A growing number of hereditary monogenic rare diseases has been identified, leading to a better understanding of molecular processes even in multifactorial diseases. In addition to genomics, other omics-technologies (e.g. transcriptomics, metabolomics, proteomics, immunomics) complement our scientific armamentarium to comprehensively assess states of diseases. A challenge of these technologies is to integrate and interpret these large datasets. Emerging data suggest that combining multi-layer omics data with digital clinical data will allow us to improve diagnostics, to optimize prevention, and to design definitive cures. Advances in machine learning enabling pattern recognition and statistical associations, offer new perspectives for developing innovative and non-invasive diagnostic methods.

                                                                                  In the context of this non-randomized, monocentric observation study, the benefit of using a combination of pattern recognition of image data of the retina by fundus photography and optical coherence tomography (OCT) in combination with the analysis of various OMICS data (genome, transcriptome, proteome and metabolome) will be explored in search of markers for rare and chronic childhood diseases. Retinal images and OMICS data are pseudonymized and subjected to machine learning algorithms. Starting from classical nosological entities, we will compare the data not only within defined groups but also across phenotypes, aiming to shed light on pleiotropic factors. Once associations between genomic and phenotypic data sets become apparent, new hypotheses will be developed and tested in suitable model systems. 

                                                                                  Multi-OMICS methods

                                                                                  Content will follow shortly.

                                                                                  A.I. analysis

                                                                                  Content will follow shortly.

                                                                                • Inquieries only via the official e-mail adress: Scivias.Hauner@med.uni-muenchen.de

                                                                                  Prof. Dr. med. Dr. sci. nat.  Christoph Klein
                                                                                  Studienleitung/Chefarzt
                                                                                  more on the person
                                                                                  Dr. med. Katharina Danhauser
                                                                                  Stellvertretende Studienleitung
                                                                                  ÜgbzgplugeMguzgfcipvim-fulhvfiuyziuemi
                                                                                  more on the person
                                                                                  PD Dr. Claudia Priglinger 
                                                                                  Stellvertretend Studienleitung Augenklinik
                                                                                  HägfmlgsPplxäluxipvim-ful#vfiuyWziu mi
                                                                                  Dr. med. Anna-Lisa Lanz
                                                                                  OMICs-Labor, Laborleitung
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                                                                                  Larissa Mantoan
                                                                                  Studienärztin
                                                                                  VgpJlccag-Ogubnüguvim ful_vfiuyziu mi
                                                                                  more on the person
                                                                                  Dr. med. Rebekka Astudillo, DTMIH
                                                                                  Studienärztin
                                                                                  Bijioog Fcbfmläa,äüvimY-ful_vfiuyaziuemi
                                                                                  more on the person
                                                                                  Dr. med. Selina Gläser
                                                                                  Studienärztin
                                                                                  RiDdäJlSugtXägicipvim ful+vfiuyziu mi
                                                                                  more on the person
                                                                                  Dominik Knebel
                                                                                  Wissenschaftlicher Mitarbeiter Augenklinik
                                                                                  MüvlWulo/ÜuijiävimsfulGvfiuyzYiuemi
                                                                                  more on the person
                                                                                  Dr. Benedikt Schworm 
                                                                                  Wissenschaftlicher Mitarbeiter Augenklinik
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                                                                                  Sachiko Kwaschnowitz; M.Sc.
                                                                                  Study Nurse
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                                                                                  Karla Strniscak
                                                                                  Projektmitarbeiterin, MFA
                                                                                  Ügp;ägJtRDbpulcyg,ovimefulhvfiuyziu-mi
                                                                                  more on the person
                                                                                  Monika Prothmann
                                                                                  OMICs-Labor, leitende TA
                                                                                  vüulogeöpübzvguuvim ful+vfiuyziu-mi
                                                                                  Daniel Weiß
                                                                                  Informatiker
                                                                                  M;gulaiä-Uilccvim-ful_vfiuyziu-mi
                                                                                  Dr. Susanne Pangratz-Fuehrer
                                                                                  Wissenschaftliche Mitarbeiterin, Projekt Management
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                                                                                  Prof. Dr. med. Dr. sci. nat.  Christoph Klein
                                                                                  Studienleitung/Chefarzt
                                                                                  more on the person
                                                                                  Dr. med. Katharina Danhauser
                                                                                  Stellvertretende Studienleitung
                                                                                  ÜgbzgSdplug-MguzgfcipvimefuYlGvfiuyziu: mi
                                                                                  more on the person
                                                                                  PD Dr. Claudia Priglinger 
                                                                                  Stellvertretend Studienleitung Augenklinik
                                                                                  HägfmlgePplxäluxipvim-fulGvfiuyziuemi
                                                                                  Dr. med. Anna-Lisa Lanz
                                                                                  OMICs-Labor, Laborleitung
                                                                                  FuuJWgVlcg Vgußvim-ful_vfiuayWziu mi
                                                                                  Larissa Mantoan
                                                                                  Studienärztin
                                                                                  :Vgplccg OngubSüguvimnefulhvfiuyziu/mi
                                                                                  more on the person
                                                                                  Dr. med. Rebekka Astudillo, DTMIH
                                                                                  Studienärztin
                                                                                  BijioogeFcbfYmJlääJüvim-fulhdvfiuyziuemi
                                                                                  more on the person
                                                                                  Dr. med. Selina Gläser
                                                                                  Studienärztin
                                                                                  Riälug-XäagicipYvimsful_vfiuyziutm:i
                                                                                  more on the person
                                                                                  Dominik Knebel
                                                                                  Wissenschaftlicher Mitarbeiter Augenklinik
                                                                                  MüvJluloJ-Üuijninävim fulhvfiuyziutmi
                                                                                  more on the person
                                                                                  Dr. Benedikt Schworm 
                                                                                  Wissenschaftlicher Mitarbeiter Augenklinik
                                                                                  Aiuimlob-;RyzéüJpvvim-:ful_vfiuyziuemi
                                                                                  Sachiko Kwaschnowitz; M.Sc.
                                                                                  Study Nurse
                                                                                  RgyzloüeÜégcyzuüéalbßYvimsful#vfiuyziu mi
                                                                                  Karla Strniscak
                                                                                  Projektmitarbeiterin, MFA
                                                                                  Ügpäg-Rbpulcygovim-ful_vfiuyziuemi
                                                                                  more on the person
                                                                                  Monika Prothmann
                                                                                  OMICs-Labor, leitende TA
                                                                                  vü:ulogeöpübzvguuvimsfdul_vfiuyziWue;mi
                                                                                  Daniel Weiß
                                                                                  Informatiker
                                                                                  Mguliä/UilccvimsfulGWvfiuyziu-m:i
                                                                                  Dr. Susanne Pangratz-Fuehrer
                                                                                  Wissenschaftliche Mitarbeiterin, Projekt Management
                                                                                  RfcguuitPguxpgbßÄfizpipvimefulrvfiuyziu-mi
                                                                                • Scivias Study

                                                                                  Dr. von Hauner Children's Hospital, University Hospital LMU Munich

                                                                                  Lindwurmstrasse 4
                                                                                  80337 Munich
                                                                                  Rylqlgc-Zgfuipvimeful_vfiuyziusmi

                                                                                Thank you to all donors and supporters of the Scivias study

                                                                                The Scivias study is kindly supported by Eva Mayr-Stihl Stiftung, Carl Zeiss AG and Munich Re, among others.

                                                                                Research at CCRC Hauner

                                                                                Contact LMU Klinikum

                                                                                Contact CCRC Hauner

                                                                                Haunersches

                                                                                CCRC Hauner

                                                                                Kinderklinik und Kinderpoliklinik

                                                                                im Dr. von Haunerschen Kinderspital

                                                                                Ludwig Maximilians Universität München

                                                                                Lindwurmstr. 4

                                                                                80337 Munich, Germany

                                                                                ☎ +49-89-4400-57705

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                                                                                • Deutsch - de
                                                                                • English - en

                                                                                Comprehensiv...

                                                                                • Clinical research
                                                                                  • Interdisciplinary pediatric study center (Hauner iPSC)
                                                                                  • Ped-COVID-19 Study
                                                                                  • Michael Albert
                                                                                  • Scivias Study
                                                                                  • TRACE Study
                                                                                  • ImmGenDC Study
                                                                                  • Hematology/Oncology/Coagulation
                                                                                • Research Labs
                                                                                  • Binder Lab
                                                                                  • Bohlen Lab
                                                                                  • Braun Lab
                                                                                  • Griese Lab
                                                                                  • Hauck Lab
                                                                                  • Hübner Lab
                                                                                  • Jeremias lab
                                                                                  • Kim-Hellmuth Lab
                                                                                  • Klein Lab
                                                                                  • Koletzko Lab
                                                                                  • Kotlarz Lab
                                                                                  • Lange-Sperandio Lab
                                                                                  • von Mutius Lab
                                                                                  • Nußbaum Lab
                                                                                  • Rosenecker Lab
                                                                                  • Schaub Lab
                                                                                  • Schmid Lab
                                                                                  • Schwerd Lab
                                                                                • PhD Program
                                                                                • Technology platforms
                                                                                  • Bioinformatics
                                                                                  • Flow Cytometry
                                                                                  • High throughput sequencing
                                                                                  • Microscopy
                                                                                  • Pre-GMP Facility
                                                                                  • Mass spectrometry
                                                                                  • Hauner Biobank
                                                                                  • Organoid Lab
                                                                                  • Humangenetik am Hauner
                                                                                • News/Events
                                                                                  • News
                                                                                  • Rare Disease Day
                                                                                  • ECHO-Meeting
                                                                                  • Meinhard von Pfaundler-Lectures
                                                                                  • Klaus Betke Symposium
                                                                                • Join us!