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                                                                                  1. CCRC-HaunerEN
                                                                                  2. Clinical research
                                                                                  3. Scivias Study

                                                                                  Scivias Study

                                                                                  • Aims of the Study:


                                                                                    • Identification of new biomarkers for the overall assessment of the systemic health status of childrenDevelopment of a novel diagnostic tool in children 
                                                                                    • Establishment of a normal range for fundus photography, OCT and OCT angiography with regard to retinal changes in various age groups

                                                                                    • Evaluation of the value of optical fundus evaluation in (early) diagnosis of a rare disease
                                                                                    • Establishing a reference range for changes in the transcriptome, metabolome and proteome in various age groups and in various acute and chronic diseases
                                                                                    • Correlation of systems biology data with disease activities of rare diseases
                                                                                    • Specification of phenotyping of patients within different disease groups

                                                                                  • Scivias Study

                                                                                    Project Summary

                                                                                    Early detection of diseases is a central challenge for pediatric medicine. The earlier a disease is discovered, the easier it is to avoid complications and sequelae and to reduce long-term morbidity. This is particularly relevant for children with rare diseases in whom the diagnostic process is often delayed. Children with rare and chronic diseases are usually only diagnosed when their disease manifests or complications arise. Thus, there is an urgent need to develop and use new sensitive and specific diagnostic methods, preferably as non-invasive as possible.

                                                                                    Next generation sequencing technologies have revolutionized human genetics. A growing number of hereditary monogenic rare diseases has been identified, leading to a better understanding of molecular processes even in multifactorial diseases. In addition to genomics, other omics-technologies (e.g. transcriptomics, metabolomics, proteomics, immunomics) complement our scientific armamentarium to comprehensively assess states of diseases. A challenge of these technologies is to integrate and interpret these large datasets. Emerging data suggest that combining multi-layer omics data with digital clinical data will allow us to improve diagnostics, to optimize prevention, and to design definitive cures. Advances in machine learning enabling pattern recognition and statistical associations, offer new perspectives for developing innovative and non-invasive diagnostic methods.

                                                                                    In the context of this non-randomized, monocentric observation study, the benefit of using a combination of pattern recognition of image data of the retina by fundus photography and optical coherence tomography (OCT) in combination with the analysis of various OMICS data (genome, transcriptome, proteome and metabolome) will be explored in search of markers for rare and chronic childhood diseases. Retinal images and OMICS data are pseudonymized and subjected to machine learning algorithms. Starting from classical nosological entities, we will compare the data not only within defined groups but also across phenotypes, aiming to shed light on pleiotropic factors. Once associations between genomic and phenotypic data sets become apparent, new hypotheses will be developed and tested in suitable model systems. 

                                                                                    Multi-OMICS methods

                                                                                    Content will follow shortly.

                                                                                    A.I. analysis

                                                                                    Content will follow shortly.

                                                                                  • Inquieries only via the official e-mail adress: Scivias.Hauner@med.uni-muenchen.de

                                                                                    Prof. Dr. med. Dr. sci. nat.  Christoph Klein
                                                                                    Studienleitung/Chefarzt
                                                                                    more on the person
                                                                                    Dr. med. Katharina Danhauser
                                                                                    Stellvertretende Studienleitung
                                                                                    Ügbzgplug-MguzgfcipvidmsfulGvfiuyziusmi
                                                                                    more on the person
                                                                                    PD Dr. Claudia Priglinger 
                                                                                    Stellvertretend Studienleitung Augenklinik
                                                                                    Hägfmlg Pplxäluxipvim-ful+vfiuyziu-mi
                                                                                    Dr. med. Anna-Lisa Lanz
                                                                                    OMICs-Labor, Laborleitung
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                                                                                    Larissa Mantoan
                                                                                    Studienärztin
                                                                                    VgplccgeOgubüguvimsful+vYfiuyziu-mi
                                                                                    more on the person
                                                                                    Dr. med. Rebekka Astudillo, DTMIH
                                                                                    Studienärztin
                                                                                    BijioogeFcbfmlääüvim f,ulGvfiuyziuemi
                                                                                    more on the person
                                                                                    Dr. med. Selina Gläser
                                                                                    Studienärztin
                                                                                    RiälugsXägicipvimsful_vfiuyziu/mi
                                                                                    more on the person
                                                                                    Dominik Knebel
                                                                                    Wissenschaftlicher Mitarbeiter Augenklinik
                                                                                    Müvlul:oeÜ,JuijiäviDm fulGvfiuyziu mi
                                                                                    more on the person
                                                                                    Dr. Benedikt Schworm 
                                                                                    Wissenschaftlicher Mitarbeiter Augenklinik
                                                                                    AiuimlobsnRyzéüpvvim/fulJrvfiuyz,iu mi
                                                                                    Sachiko Kwaschnowitz; M.Sc.
                                                                                    Study Nurse
                                                                                    Rgyzloü Üégcyzuüélbßvimeful_vfiuyziusmi
                                                                                    Karla Strniscak
                                                                                    Projektmitarbeiterin, MFA
                                                                                    ÜgpägeR:bpnulncygoJvim ful_vfiuyziutmi
                                                                                    more on the person
                                                                                    Monika Prothmann
                                                                                    OMICs-Labor, leitende TA
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                                                                                    Daniel Weiß
                                                                                    Informatiker
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                                                                                    Dr. Susanne Pangratz-Fuehrer
                                                                                    Wissenschaftliche Mitarbeiterin, Projekt Management
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                                                                                    Prof. Dr. med. Dr. sci. nat.  Christoph Klein
                                                                                    Studienleitung/Chefarzt
                                                                                    more on the person
                                                                                    Dr. med. Katharina Danhauser
                                                                                    Stellvertretende Studienleitung
                                                                                    Ügbzgplug Mguzgfcipvim-fulhvfiuyziu mi
                                                                                    more on the person
                                                                                    PD Dr. Claudia Priglinger 
                                                                                    Stellvertretend Studienleitung Augenklinik
                                                                                    Hägfmlg Pplxäluxipvim ful#vfiuyziusmi
                                                                                    Dr. med. Anna-Lisa Lanz
                                                                                    OMICs-Labor, Laborleitung
                                                                                    FuugVlcgeVgußvim;-ful_vfiuyziusmi
                                                                                    Larissa Mantoan
                                                                                    Studienärztin
                                                                                    VgYplccg-,Ogubüguvim ful_vfiuyziusmi
                                                                                    more on the person
                                                                                    Dr. med. Rebekka Astudillo, DTMIH
                                                                                    Studienärztin
                                                                                    Bdijioog Fcbfmlääüvima Sfulhvfiuyziu mi
                                                                                    more on the person
                                                                                    Dr. med. Selina Gläser
                                                                                    Studienärztin
                                                                                    RiWälug/Xägicipvimeful_vfiuyziutmi
                                                                                    more on the person
                                                                                    Dominik Knebel
                                                                                    Wissenschaftlicher Mitarbeiter Augenklinik
                                                                                    Müvlulo Üuijiävim ful+vfiuyziusmi
                                                                                    more on the person
                                                                                    Dr. Benedikt Schworm 
                                                                                    Wissenschaftlicher Mitarbeiter Augenklinik
                                                                                    Aiuimddlob Ryzéüpvvim-ful_vfiuy,ziu mi
                                                                                    Sachiko Kwaschnowitz; M.Sc.
                                                                                    Study Nurse
                                                                                    Rgyzloü Üégcyzuüélbßvim fulGvfiuyziu-mi
                                                                                    Karla Strniscak
                                                                                    Projektmitarbeiterin, MFA
                                                                                    ÜgpägsRbpulcygovim/fulhvfiuyziu/mi
                                                                                    more on the person
                                                                                    Monika Prothmann
                                                                                    OMICs-Labor, leitende TA
                                                                                    vüulog öpübzvguuvimsfulJrvfiuyziu:snmni
                                                                                    Daniel Weiß
                                                                                    Informatiker
                                                                                    JMguliä-UilcJcvim-ful_vfiYuyz,iu mi
                                                                                    Dr. Susanne Pangratz-Fuehrer
                                                                                    Wissenschaftliche Mitarbeiterin, Projekt Management
                                                                                    RfcguYui PguxpgbßÄfJizpipvim-ful_vfiuyzi,usmi
                                                                                  • Scivias Study

                                                                                    Dr. von Hauner Children's Hospital, University Hospital LMU Munich

                                                                                    Lindwurmstrasse 4
                                                                                    80337 Munich
                                                                                    Rylqlagc-Zgfauipvim Wful+Jvfiuyziu mi

                                                                                  Thank you to all donors and supporters of the Scivias study

                                                                                  The Scivias study is kindly supported by Eva Mayr-Stihl Stiftung, Carl Zeiss AG and Munich Re, among others.

                                                                                  Research at CCRC Hauner

                                                                                  Contact LMU Klinikum

                                                                                  Contact CCRC Hauner

                                                                                  Haunersches

                                                                                  CCRC Hauner

                                                                                  Kinderklinik und Kinderpoliklinik

                                                                                  im Dr. von Haunerschen Kinderspital

                                                                                  Ludwig Maximilians Universität München

                                                                                  Lindwurmstr. 4

                                                                                  80337 Munich, Germany

                                                                                  ☎ +49-89-4400-57705

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                                                                                  Comprehensiv...

                                                                                  • Clinical research
                                                                                    • Interdisciplinary pediatric study center (Hauner iPSC)
                                                                                    • Ped-COVID-19 Study
                                                                                    • Michael Albert
                                                                                    • Scivias Study
                                                                                    • TRACE Study
                                                                                    • ImmGenDC Study
                                                                                    • Hematology/Oncology/Coagulation
                                                                                  • Research Labs
                                                                                    • Binder Lab
                                                                                    • Bohlen Lab
                                                                                    • Braun Lab
                                                                                    • Gaertner Lab
                                                                                    • Griese Lab
                                                                                    • Hauck Lab
                                                                                    • Hübner Lab
                                                                                    • Jeremias lab
                                                                                    • Kim-Hellmuth Lab
                                                                                    • Klein Lab
                                                                                    • Koletzko Lab
                                                                                    • Kotlarz Lab
                                                                                    • Lange-Sperandio Lab
                                                                                    • von Mutius Lab
                                                                                    • Nußbaum Lab
                                                                                    • Rosenecker Lab
                                                                                    • Schaub Lab
                                                                                    • Schmid Lab
                                                                                    • Schwerd Lab
                                                                                  • PhD Program
                                                                                  • Technology platforms
                                                                                    • Bioinformatics
                                                                                    • Flow Cytometry
                                                                                    • High throughput sequencing
                                                                                    • Microscopy
                                                                                    • Pre-GMP Facility
                                                                                    • Mass spectrometry
                                                                                    • Hauner Biobank
                                                                                    • Organoid Lab
                                                                                    • Humangenetik am Hauner
                                                                                  • News/Events
                                                                                    • News
                                                                                    • Rare Disease Day
                                                                                    • ECHO-Meeting
                                                                                    • Meinhard von Pfaundler-Lectures
                                                                                    • Klaus Betke Symposium
                                                                                  • Join us!