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                                                                                  1. CCRC-HaunerEN
                                                                                  2. Research Labs
                                                                                  3. Lange-Sperandio Lab

                                                                                  Lange-Sperandio Lab

                                                                                  • Copyright unknown

                                                                                    • Congenital anomalies of kidneys and urinary tract (CAKUT)
                                                                                    • Inflammation and fibrosis
                                                                                    • Kidney development
                                                                                    • Biomarkers in kidney diseases

                                                                                    Prof. Dr. med. Bärbel Lange-Sperandio

                                                                                    ✉ baerbel.lange-sperandio@med.uni-muenchen.de

                                                                                    ☎ +49-89-4400-52811

                                                                                  • Congenital anomalies of kidney and urinary tract (CAKUT) are the leading cause of end stage renal disease (ESRD) in children. CAKUT represents a wide spectrum of isolated unilateral or bilateral malformations. We are interested in discovering the causes of chronic renal failure following congenital obstruction of the urinary tract. We study obstructive uropathies in vitro and in vivo using newborn rodents. Our research group aims to identify molecular mechanisms, specific signaling pathways and mediators of inflammation and fibrosis in the developing kidney with obstruction. Our goal is to improve diagnostic and therapeutic strategies in children with CAKUT.

                                                                                  • Copyright unknown

                                                                                    Prof. Dr. Bärbel Lange-Sperandio

                                                                                    Dr. Katharina Hermes

                                                                                    Maja Wyczanska (M.Sc.)

                                                                                    Ursula Keller

                                                                                  • Selected Publications

                                                                                    Gasparitsch M, Schieber A, Schaubeck T, Keller U, Cattaruzza M, Lange-Sperandio B. Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy. PloS One (2019), 14(12), e0226675.

                                                                                    Popper B, Rammer M T, Gasparitsch M, Singer T, Keller U, Döring Y, Lange-Sperandio B. Neonatal obstructive nephropathy induces necroptosis and necroinflammation. Scientific Reports (2019), 9(1), 1–11

                                                                                    Lange-Sperandio, B., Pediatric Obstructive Uropathy, in Pediatric Nephrology, D.E. Avner, Harmon, E.W., Niaudet, P., Yoshikawa, N., Emma, F., Goldstein L.S., Editor. 2016, Springer Berlin Heidelberg: Berlin, Heidelberg. p. 1749-1777.

                                                                                    Gasparitsch M, Arndt AK, Pawlitschek F, Oberle S, Keller U, Kasper M, Bierhaus A, Schaefer F, Weber LT, Lange-Sperandio B. RAGE-mediated interstitial fibrosis in neonatal obstructive nephropathy is independent of NF-κB activation. Kidney Int. 2013 Nov;84(5):911-9.

                                                                                    RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner. Frommhold D, Kamphues A, Dannenberg S, Buschmann K, Zablotskaya V, Tschada R, Lange-Sperandio B, Nawroth PP, Poeschl J, Bierhaus A, Sperandio M. BMC Immunol. 2011 Oct 4;12:56.

                                                                                    Lange-Sperandio B, Trautmann A, Eickelberg O, Jayachandran A, Oberle S, Schmidutz F, Rodenbeck B, Hömme M, Horuk R, Schaefer F. Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice. Am J Pathol. 2007 Sep;171(3):861-71.

                                                                                    Lange-Sperandio B, Schimpgen K, Rodenbeck B, Chavakis T, Bierhaus A, Nawroth P, Thornhill B, Schaefer F, Chevalier RL. Distinct roles of Mac-1 and its counter-receptors in neonatal obstructive nephropathy. Kidney Int. 2006 Jan;69(1):81-8.

                                                                                  • Prof. Dr. med. Bärbel Lange-Sperandio


                                                                                    ✉ baerbel.lange-sperandio@med.uni-muenchen.de


                                                                                    Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital,

                                                                                    Klinikum der Universität München, LMU München


                                                                                    Postal Address: Lindwurmstr. 4

                                                                                    Visiting Address: Research Building, Lindwurmstraße 2a

                                                                                    80337 Munich

                                                                                    Germany


                                                                                    ☎ +49-89-4400-52811

                                                                                  Research at CCRC Hauner

                                                                                  Contact LMU Klinikum

                                                                                  Contact CCRC Hauner

                                                                                  Haunersches

                                                                                  CCRC Hauner

                                                                                  Kinderklinik und Kinderpoliklinik

                                                                                  im Dr. von Haunerschen Kinderspital

                                                                                  Ludwig Maximilians Universität München

                                                                                  Lindwurmstr. 4

                                                                                  80337 Munich, Germany

                                                                                  ☎ +49-89-4400-57705

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                                                                                  • Deutsch - de
                                                                                  • English - en

                                                                                  Comprehensiv...

                                                                                  • Clinical research
                                                                                    • Interdisciplinary pediatric study center (Hauner iPSC)
                                                                                    • Ped-COVID-19 Study
                                                                                    • Michael Albert
                                                                                    • Scivias Study
                                                                                    • TRACE Study
                                                                                    • ImmGenDC Study
                                                                                    • Hematology/Oncology/Coagulation
                                                                                  • Research Labs
                                                                                    • Binder Lab
                                                                                    • Bohlen Lab
                                                                                    • Braun Lab
                                                                                    • Gaertner Lab
                                                                                    • Griese Lab
                                                                                    • Hauck Lab
                                                                                    • Hübner Lab
                                                                                    • Jeremias lab
                                                                                    • Kim-Hellmuth Lab
                                                                                    • Klein Lab
                                                                                    • Koletzko Lab
                                                                                    • Kotlarz Lab
                                                                                    • Lange-Sperandio Lab
                                                                                    • von Mutius Lab
                                                                                    • Nußbaum Lab
                                                                                    • Rosenecker Lab
                                                                                    • Schaub Lab
                                                                                    • Schmid Lab
                                                                                    • Schwerd Lab
                                                                                  • PhD Program
                                                                                  • Technology platforms
                                                                                    • Bioinformatics
                                                                                    • Flow Cytometry
                                                                                    • High throughput sequencing
                                                                                    • Microscopy
                                                                                    • Pre-GMP Facility
                                                                                    • Mass spectrometry
                                                                                    • Hauner Biobank
                                                                                    • Organoid Lab
                                                                                    • Humangenetik am Hauner
                                                                                  • News/Events
                                                                                    • News
                                                                                    • Rare Disease Day
                                                                                    • ECHO-Meeting
                                                                                    • Meinhard von Pfaundler-Lectures
                                                                                    • Klaus Betke Symposium
                                                                                  • Join us!