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                                                                                Bohlen Lab

                                                                                • Research topics


                                                                                  • Translational Regulation in Immune Cells
                                                                                    Unravelling how mRNA translation governs the function of leukocytes and other key immune cells.
                                                                                  • Inborn Errors of Immunity


                                                                                    Investigating genetic defects—ranging from disruptions in mRNA translation to other mutations—that underlie immune pathologies including infections, autoinflammation and autoimmunity
                                                                                  • Molecular Mechanisms of Immune Dysregulation

                                                                                    Dissecting the pathways and cellular consequences of aberrant protein synthesis and its link to immune disorders.

                                                                                  Dr. Jonathan Bohlen

                                                                                  ✉ bohlen@genzentrum.lmu.de

                                                                                  ☎ +49-89-2180 71055

                                                                                • Research Summary

                                                                                  Our lab is dedicated to understanding the molecular underpinnings of the human immune system. By focusing on the regulation of mRNA translation in leukocytes, we aim to illuminate how subtle disruptions in protein synthesis can lead to profound clinical consequences. Our work not only targets defects in the translational machinery but also encompasses a broader spectrum of genetic errors that compromise immune function. This research is critical to bridging the gap between fundamental molecular biology and clinical insights into immunodeficiency and auto-inflammatory conditions.

                                                                                  Our approach

                                                                                  We leverage primary human leukocytes as a model system, combining advanced molecular biology techniques with cutting-edge genomics and bioinformatics. Our multidisciplinary approach integrates clinical data and patient-derived samples to pinpoint the molecular drivers of immune dysfunction. This robust strategy is designed to pave the way for novel diagnostics and therapeutic interventions in patients with rare, severe immunological disorders.


                                                                                • Ivan Bagaric

                                                                                  Doctoral Researcher

                                                                                  ✉ bagaric@genzentrum.lmu.de


                                                                                  Taja Vatovec

                                                                                  Doctoral Researcher

                                                                                  ✉ vatovec@genzentrum.lmu.de


                                                                                  Dr. Jonathan Bohlen 

                                                                                  Group Leader

                                                                                  ✉ bohlen@genzentrum.lmu.de

                                                                                • Selected Publications

                                                                                  Autoinflammation in patients with leukocytic CBL loss of heterozygosity is caused by constitutive ERK-mediated monocyte activation. Bohlen J, Bagarić I, Vatovec T, Ogishi M, Ahmed SF, Cederholm A, Buetow L, Sobrino S, Le Floc'h C, Arango-Franco CA, Seabra L, Michelet M, Barzaghi F, Leardini D, Saettini F, Vendemini F, Baccelli F, Catala A, Gambineri E, Veltroni M, Aguilar de la Red Y, Rice GI, Consonni F, Berteloot L, Largeaud L, Conti F, Roullion C, Masson C, Bessot B, Seeleuthner Y, Le Voyer T, Rinchai D, Rosain J, Neehus AL, Erazo-Borrás L, Li H, Janda Z, Cho EJ, Muratore E, Soudée C, Lainé C, Delabesse E, Goulvestre C, Ma CS, Puel A, Tangye SG, André I, Bole-Feysot C, Abel L, Erlacher M, Zhang SY, Béziat V, Lagresle-Peyrou C, Six E, Pasquet M, Alsina L, Aiuti A, Zhang P, Crow YJ, Landegren N, Masetti R, Huang DT, Casanova JL, Bustamante J.; J Clin Invest. 2024 Oct 15;134(20):e181604. doi: 10.1172/JCI181604. PubMed


                                                                                  Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria. Bohlen J, Zhou Q, Philippot Q, Ogishi M, Rinchai D, Nieminen T, Seyedpour S, Parvaneh N, Rezaei N, Yazdanpanah N, Momenilandi M, Conil C, Neehus AL, Schmidt C, Arango-Franco CA, Voyer TL, Khan T, Yang R, Puchan J, Erazo L, Roiuk M, Vatovec T, Janda Z, Bagarić I, Materna M, Gervais A, Li H, Rosain J, Peel JN, Seeleuthner Y, Han JE, L'Honneur AS, Moncada-Vélez M, Martin-Fernandez M, Horesh ME, Kochetkov T, Schmidt M, AlShehri MA, Salo E, Saxen H, ElGhazali G, Yatim A, Soudée C, Sallusto F, Ensser A, Marr N, Zhang P, Bogunovic D, Cobat A, Shahrooei M, Béziat V, Abel L, Wang X, Boisson-Dupuis S, Teleman AA, Bustamante J, Zhang Q, Casanova JL.; Cell. 2023 Nov 9;186(23):5114-5134.e27. PubMed


                                                                                  PRRC2 proteins impact translation initiation by promoting leaky scanning. Bohlen J, Roiuk M, Neff M, Teleman AA.; Nucleic Acids Res. 2023 Apr 24;51(7):3391-3409. PubMed


                                                                                  Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells. Bohlen J, Fenzl K, Kramer G, Bukau B, Teleman AA.; Mol Cell. 2020 Aug 20;79(4):561-574.e5. PubMed

                                                                                  More publications Bohlen Lab
                                                                                • JOIN OUR TEAM

                                                                                  Join us!

                                                                                  We invite motivated students and researchers with a passion for immunogenetics and regulation of gene expression to join our collaborative efforts. Together, we strive to uncover the genetic foundations of immune system regulation and translate these findings into clinical benefit. 

                                                                                • Bohlen Lab - Contact

                                                                                  Dr. Jonathan Bohlen

                                                                                  Gene Center

                                                                                  Ludwig-Maximilians-Universität München

                                                                                  Postal Address: Feodor-Lynen-Straße 25

                                                                                  Visiting Address: BioSysM, Butenandtstraße 1

                                                                                  81377 Munich, Germany

                                                                                  Room: K 01.040

                                                                                  Phone: +49 (0)89 - 2180 71055

                                                                                  Email: bohlen@genzentrum.lmu.de

                                                                                Research at CCRC Hauner

                                                                                Contact LMU Klinikum

                                                                                Contact CCRC Hauner

                                                                                Haunersches

                                                                                CCRC Hauner

                                                                                Kinderklinik und Kinderpoliklinik

                                                                                im Dr. von Haunerschen Kinderspital

                                                                                Ludwig Maximilians Universität München

                                                                                Lindwurmstr. 4

                                                                                80337 Munich, Germany

                                                                                ☎ +49-89-4400-57705

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                                                                                • Clinical research
                                                                                  • Interdisciplinary pediatric study center (Hauner iPSC)
                                                                                  • Ped-COVID-19 Study
                                                                                  • Michael Albert
                                                                                  • Scivias Study
                                                                                  • TRACE Study
                                                                                  • ImmGenDC Study
                                                                                  • Hematology/Oncology/Coagulation
                                                                                • Research Labs
                                                                                  • Binder Lab
                                                                                  • Bohlen Lab
                                                                                  • Braun Lab
                                                                                  • Griese Lab
                                                                                  • Hauck Lab
                                                                                  • Hübner Lab
                                                                                  • Jeremias lab
                                                                                  • Kim-Hellmuth Lab
                                                                                  • Klein Lab
                                                                                  • Koletzko Lab
                                                                                  • Kotlarz Lab
                                                                                  • Lange-Sperandio Lab
                                                                                  • von Mutius Lab
                                                                                  • Nußbaum Lab
                                                                                  • Rosenecker Lab
                                                                                  • Schaub Lab
                                                                                  • Schmid Lab
                                                                                  • Schwerd Lab
                                                                                • PhD Program
                                                                                • Technology platforms
                                                                                  • Bioinformatics
                                                                                  • Flow Cytometry
                                                                                  • High throughput sequencing
                                                                                  • Microscopy
                                                                                  • Pre-GMP Facility
                                                                                  • Mass spectrometry
                                                                                  • Hauner Biobank
                                                                                  • Organoid Lab
                                                                                  • Humangenetik am Hauner
                                                                                • News/Events
                                                                                  • News
                                                                                  • Rare Disease Day
                                                                                  • ECHO-Meeting
                                                                                  • Meinhard von Pfaundler-Lectures
                                                                                  • Klaus Betke Symposium
                                                                                • Join us!