Koletzko Lab
Subgroups
- Child and Family Health Academy (ChiFHA)
- Child Health Foundation (CHF)
- MS-Core Facility
- Clinical Study
Prof. Dr. med. Berthold Koletzko
✉ Berthold.Koletzko@med.uni-muenchen.de
☎ +49-89-4400-52826
Four subgroups of Prof. Koletzko consist of Child and Familiy Health Academy (ChiFHA), Child Health Foundation, MS-Core Facility and Clinical Study.
The Child and Family Health Academy (ChiFHA) offers high-quality, up-to-date and evidence-based training and continuing professional development programmes, covering a broad spectrum of health-related topics with a focus on the healthy development and well-being of children and their families. Our global target audience comprises doctors, healthcare professionals, researchers and students who wish to contribute to improving healthcare for children and families through targeted medical training.
ChiFHA’s vision is to be a globally recognized leading academy in the field of child and family health. Our free continuing professional development programmes are available online and via blended learning, making them accessible to everyone, anywhere, at any time. Our aim is to promote and improve the global health of children from the earliest stages of life. To this end, we offer both global and regional programmes that address the distinct needs of individual regions and align with the relevant regional guidelines.
The global programmes comprise projects:
- Early Nutrition e-Academy (ENeA Global)
- Massive Open Online Course (MOOC) “Breastfeeding and Adequate Substitutes” and “Nutrition and Lifestyle in Pregnancy”
- Early Nutrition Specialist Master Class (ENS Master Class)
- Early Nutrition Course for Midwives (ENCoMs)
The regional programmes comprise projects:
- Lernplattform rund um die Ernährung von Anfang an (LEVa)
- Education and Training of Health Care Personnel for Sustainable Early Prevention of Non-Communicable Diseases in Indonesia (EATS INA)
- Improving Early Nutrition and Health in South Africa (ImpENSA)
- Early Nutrition eAcademy South East Asia (ENeA SEA)
- Celiac Disease (CD) Skills.
More information about ChiFHA at https://chifha.org
The Child Health Foundation (CHF) is committed to promoting the healthy development of children and adolescents. It informs the public about key health issues and, in collaboration with partners and specialists, promotes preventive strategies that can be implemented in day care centres, kindergartens, and schools.
The foundation's work is based on three pillars:
- Practice-oriented prevention programs
- Expertise in health prevention
- Effective public education
Health promotion and prevention are especially important for children. Today, paediatric and adolescent medicine is able to successfully treat a wide range of illnesses. Yet health promotion and disease prevention still require significant efforts and remain key priorities. Ultimately, the main goal of the CHF is to ensure the best possible start in life for every child.
More information about the Child Health Foundation is available at https://www.kindergesundheit.de/
The MS-Core Facility in the Dr. von Hauner Children´s Hospital performs targeted LC-MS/MS based analysis of biological samples such as plasma, serum, milk and tissue from humans as well as animals from small research studies (e.g. elephant milk, cat plasma and mouse tissue) to medium and large clinical cohort studies (e.g. HOPE, RisCoin, CORKUM, ToMi and CHOP). The MS-Core Facility team works in close collaboration with in-house LMU-Klinikum research groups as well as research groups from other international universities and companies to facilitate correct sample collection, processing, storage and shipment. Hence, we offer and provide support already during the planning and writing stage of a clinical study, which includes stablishing a suitable budget plan as well as setting up material transfer agreements. In addition, we also offer help and assistance for statistical data evaluation of LC-MS generated metabolome and lipidome data sets.
Our metabolomics platform analysis includes amino acids (20 proteinogenic AAs plus Cit and Orn), organic acids and keto-acids from the TCA-cycle (15), acyl-carnitins (60) and glycerophosphocholines (PCaa, PCae, LPCa, LPCe and SM; a = acyl and e = ether; 320). Besides that, we also perform method development for sample preparation and quantitative analysis of free short, medium and long chain fatty acids, endocannabinoids, bile acids and lipid hydrolysis, among others. In addition, we have established the Biocrates MxP Quant 500XL (Lipidomics) and MxP Quant 1000 Kit (Metabolomics) analysis for plasma, breast milk and tissue homogenate on our Sciex QTRAP 6500+ mass spectrometer. For further information, please visit our MS-Core Facility webpage:
https://www.ccrc-hauner.de/technology-platforms/mass-spectrometry/d990e77de89f6bfb
The nutritional study team conducts research on nutrition in early life and its long-term health consequences. Currently, the following studies and projects are ongoing or have been recently finished:
Studies:
- CHOP (Childhood Obesity Project): A long term follow-up of a cohort that included an intervention with infant formula with differing protein content during the first year of life in five European countries. Multiple study visits with anthropometric measurements including body composition, blood and urine samples, metablomics and lipidomics, genom- and epigenomwide association studies (GWAS and EWAS), physical activity and psychometric outcomes have been included. Currently, the follow-up in 20 years old adults is performed.
- GIRAFFE-study (Goat infant formula feeding and eczema study): Intervention study to examine the effect of goat and cow milk consumption on the development of allergic diseases. The study is conducted in 10 Polish and Spanish centers with about 2100 children. More information: Giraffe Study – Goat Infant Formula Feeding and Eczema study (giraffe-study.com) ; https://bmjopen.bmj.com/content/13/4/e070533
- HOPE: Observational study with the aims to characterize human milk lipids with bioactive potential and the impact of maternal diabetes mellitus on human milk during the first four month of life. More information: HOPE-Studie | LMU Klinikum (lmu-klinikum.de)
- ToMI (Toddler milk intervention trial): Trial with about 1600 children looking at the effect of protein intake during the second year of life on growth, development and metabolism. Currently, the follow-up with six years is performed. Further information: Tomi Studie | LMU Klinikum (lmu-klinikum.de) ; https://bmjopen.bmj.com/content/11/12/e048290
- ProtEUs: Intervention study to examine the effects of an infant formula with an optimized amino acid composition on growth and development during the first year of life. The trial has been terminated in 2023 with the last visit at 6 years of age.
Projects:
- BiomarKid: Biomarker signatures of diet, physical activity and sleep in children and youth. JPL/BMBF funded project. More information: Research Framework (healthydietforhealthylife.eu)
- EndObesity: Prevention of unhealthy weight gain and obesity during crucial phases throughout the lifespan. JPL/BMBF funded project. More information : EndObesity - Strategien zur Verhinderung von Übergewicht und Adipositas bei Kindern in den ersten 1000 Lebenstagen (gesundheitsforschung-bmbf.de)
- LifeCycle: Horizon 2020 project completed. The project aimed to establish an Europe- wide network of early-life cohort studies. More information: Home - LifeCycle (lifecycle-project.eu); EU Child Cohort Network
Child and Family Health Academy (ChiFHA) Team
Dr. Franziska Feldl
Associate ChiFHA Director, Head of Programmes
✉ franziska.feldl@med.uni-muenchen.de
Jennifer Stiller
Programme Manager ENS MasterClass & ENeA Hebammenwissen✉ jennifer.stiller@med.uni-muenchen.de
Martina Forro
Programme Manager ENCoMs, Admin. Project Manager, CD Skills & EATS INA
✉ martina.forro@med.uni-muenchen.de
Clinical Study Team
MS-Core Facility Team
Dr. Jeannie Horak
Laboratory Head of the MS-Core Facility
✉ Jeannie.Horak@med.uni-muenchen.de
☎ 089- 4400- 57971
Room: D1.05
Stephanie Winterstetter
Chemical Technical Assistant (CTA)
✉ StephanieKatrin.Winterstetter@med.uni-muenchen.de
Room: D1.02
Lukas Eckerlein
Chemical Technical Assistant (CTA)
✉ lukas.eckerlein@med.uni-muenchen.de
☎ 089- 4400- 57767
Raum: D1.02
Dr. Hans Demmelmair
Clinical Project Coordinator of the MS-Core Facility
✉ hans.demmelmair@med.uni-muenchen.de
☎ 089- 4400- 53692
Room: G1.16
Dr. Bernadeta Patro-Golab
Humboldt Research Fellow
(Metabolomics Data Evaluation)
✉ Bernadeta.Patrogolab@med.uni-muenchen.de
Andrii Kryshevskyi
Chemical Technical Assistant (CTA)
✉ Andrii.Kryshevskyi@med.uni-muenchen.de
☎ 089- 4400- 54613
Raum: D1.16
ImpENSA eHealthy Conversation Skills training for healthcare professionals aimed at improving micronutrient status during the first 1000 days in South Africa, Bernadeta Patro-Golab, Sunhea Choi, Jan Lukasik, Corinna Walsh, Maciej Kolodziej, Lize Havemann-Nel, Estelle Venter, Kerry Sexton, Selma Omer, Liz Goddard, Keith M Godfrey, Wendy Lawrence, Berthold Koletzko; ImpENSA Study Group (2024). PLOS Glob Public Health 4;4(12):e0003833 https://doi.org/10.1371/journal.pgph.0005780
Evaluation of ImpENSA technology-enabled behaviour change module delivered to healthcare professionals in South Africa to improve micronutrient nutrition during the first 1000 days, Sunhea Choi, Corinna Walsh, Selma Omer, Bernadeta Patro-Golab, Wendy Lawrence, Lize Havemann-Nel, Ho Ming Yuen, Berthold Koletzko, Edelweiss Wentzel-Viljoen, Michael Hendricks, Daniella Watson, Maciej Kolodziej, Jan Lukasik, Hilary Goeiman, Keith M Godfrey; ImpENSA Study Group (2024). Matern Child Nutr. 20(4):e13678 https://doi.org/10.1111/mcn.13678
Global e-Learning in Early Nutrition and Lifestyle for International Healthcare Professionals: Design and Evaluation of the Early Nutrition Specialist Programme (ENS), Brands, B., Tran, N. N., Baudendistel-Happ, E., Sanchez-Garcia, M., Fischer, M. R., & Koletzko, B. (2021). Nutrients, 13(3), 775. https://doi.org/10.3390/nu13030775
Early Nutrition eAcademy Southeast Asia e-Learning for Enhancing Knowledge on Nutrition during the First 1000 Days of Life, Brands B., Chomtho S., Suthutvoravut U., Chiong Meng Boey C., Tang, S. F., Godfrey, K. M., Koletzko, B., & For The ENeA Sea Project Group (2020). Nutrients, 12(6), 1817. https://doi.org/10.3390/nu12061817
Nutrition During Pregnancy, Lactation and Early Childhood and its Implications for Maternal and Long-Term Child Health: The Early Nutrition Project Recommendations, Koletzko, B., Godfrey, K. M., Poston, L., Szajewska, H., van Goudoever, J. B., de Waard, M., Brands, B., Grivell, R. M., Deussen, A. R., Dodd, J. M., Patro-Golab, B., Zalewski, B. M., & EarlyNutrition Project Systematic Review Group (2019). Annals of nutrition & metabolism, 74(2), 93–106. https://doi.org/10.1159/000496471
Long-Term Health Impact of Early Nutrition: The Power of Programming, Koletzko, B., Brands, B., Grote, V., Kirchberg, F. F., Prell, C., Rzehak, P., Uhl, O., Weber, M., & Early Nutrition Programming Project (2017). Annals of nutrition & metabolism, 70(3), 161–169. https://doi.org/10.1159/000477781
Curricula customization with the readerbench Framework, Gutu-Robu G., Trausan-Matu S., Dascalu M., Carabas M., Elisei A., Nistor N., Choi S., Spoerl R., & Koletzko B. (2018) Roceanu I., Beligan D., Ciolan L. & Stefan I. (eds.) In eLearning challenges and new horizons: Proceedings of the 14th International Scientific Conference "eLearning and Software for Education". National Defence University Publishing House. pp. 385-392. doi:10.12753/2066-026X-18-123
How growth due to infant nutrition influences obesity and later disease risk, Brands, B., Demmelmair, H., Koletzko, B., & EarlyNutrition Project (2014). Acta paediatrica (Oslo, Norway : 1992), 103(6), 578–585. https://doi.org/10.1111/apa.12593
Optimal nutrition in lactating women and its effect on later health of offspring: A systematic review of current evidence and recommendations (EarlyNutrition project), de Waard, M., Brands, B., Kouwenhoven, S. M. P., Lerma, J. C., Crespo-Escobar, P., Koletzko, B., Zalewski, B. M., & van Goudoever, J. B. (2017). Critical reviews in food science and nutrition, 57(18), 4003–4016. https://doi.org/10.1080/10408398.2016.1158149
Early nutrition programming of long-term health, Koletzko, B., Brands, B., Poston, L., Godfrey, K., Demmelmair, H., & Early Nutrition Project (2012). The Proceedings of the Nutrition Society, 71(3), 371–378. https://doi.org/10.1017/S0029665112000596
The Early Nutrition Programming Project (EARNEST): 5 y of successful multidisciplinary collaborative research, Koletzko, B., Brands, B., Demmelmair, H., & Early Nutrition Programming Project (2011). The American journal of clinical nutrition, 94(6 Suppl), 1749S–1753S. https://doi.org/10.3945/ajcn.110.000471
European Childhood Obesity Trial Study Group (2013). Early influences of nutrition on postnatal growth, Koletzko, B., Beyer, J., Brands, B., Demmelmair, H., Grote, V., Haile, G., Gruszfeld, D., Rzehak, P., Socha, P., Weber, M., & Nestle Nutrition Institute workshop series, 71, 11–27. https://doi.org/10.1159/000342533
The Power of Programming and the EarlyNutrition project: opportunities for health promotion by nutrition during the first thousand days of life and beyond, Koletzko, B., Brands, B., Chourdakis, M., Cramer, S., Grote, V., Hellmuth, C., Kirchberg, F., Prell, C., Rzehak, P., Uhl, O., & Weber, M. (2014). Annals of nutrition & metabolism, 64(3-4), 187–196. https://doi.org/10.1159/000365017
The effect of diet on the physical and mental development of children: views of parents and teachers in four European countries, Egan, B., Gage, H., Williams, P., Brands, B., Györei, E., López-Robles, J. C., Campoy, C., Decsi, T., Koletzko, B., & Raats, M. (2019). The British journal of nutrition, 122(s1), S31–S39. https://doi.org/10.1017/S000711451500032X
Frühkindliche Ernährung und späteres Adipositasrisiko. Hinweise auf frühe metabolische Programmierung [Infant feeding practice and later obesity risk. Indications for early metabolic programming], Koletzko, B., Schiess, S., Brands, B., Haile, G., Demmelmair, H., von Kries, R., & Grote, V. (2010). Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 53(7), 666–673. https://doi.org/10.1007/s00103-010-1079-y
Views of parents in four European countries about the effect of food on the mental performance of primary school children, Gage, H., Egan, B., Williams, P., Györei, E., Brands, B., López-Robles, J. C., Campoy, C., Koletzko, B., Decsi, T., & Raats, M. (2014). European journal of clinical nutrition, 68(1), 32–37. https://doi.org/10.1038/ejcn.2013.214
- Early Nutrition e-Academy (ENeA Global): European Union's Horizon 2020 research and innovation programme, grant agreement n. 733206; Danone Nutricia, DSM Nutrition
- Massive Open Online Course (MOOC) “Breastfeeding and Adequate Substitutes” and “Nutrition and Lifestyle in Pregnancy”: eUniversity LMU
- Early Nutrition Specialist Master Class (ENS Master Class): Société des Produits Nestlé S.A.
- Early Nutrition Course for Midwives (ENCoMs): Société des Produits Nestlé S.A.
- Lernplattform rund um die Ernährung von Anfang an (LEVa): Nestle Deutschland AG, Geschäftsbereich Nestle Nutrition GmbH
- Education and Training of Health Care Personnel for Sustainable Early Prevention of Non-Communicable Diseases in Indonesia (EATS INA): Else Kröner Fresenius Stiftung (EKFS)
- Improving Early Nutrition and Health in South Africa (ImpENSA): Erasmus+ Programme of the European Union
- Early Nutrition eAcademy South East Asia (ENeA SEA): Erasmus+ Programme of the European Union
- Celiac Disease (CD) Skills: Interreg Central Europe; Interreg Danube Transnational Programme
- BiomarKID
- RisCoin (Covid immunization study),
- COVID-19 CORKUM (metabolomics and lipidomics study, steroidomics project)
- Childhood-Obesity Programme (CHOP, RCT with long term follow up)
- Toddler Milk Intervention Trial (TOMI, NCT02907502)
Effect of milk protein intake in young children on early growth and obesity risk
- NutriPROGRAM
Multi-omics approach using 1H-NMR and LC-MS metabolomics combined with epigenetic data sets of several cohort studies (CHOP, Generation-R, Candle, etc.) for epigenetic pathway analysis
- Thailand Breast Milk Project
Normalization of milk volume produced by the mother and intake by the infant, using [2H]-labelled water; analysis of serum, cord blood, milk, Fe and Zn
- Supplementation of breastfed LBWI in Indonesia
Pilot study completed, RCT ongoing
- ERC Advanced Grant Pathophysiology of Primary Aldosteronism (PAPA)
- BiomarKid: DLR Projektträger, Förderkennzeichen 01EA2203A; European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL, BiomarKid) and German Federal Ministry of Education and Research (BMBF) programme
- CHOP: Nestec Ltd., Ave, Nestlé 55 CH-1800 Vevey, Switzerland
- EndObesity: DLR Projektträger, Förderkennzeichen 01EA2101; European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL, EndObesity) and German Federal Ministry of Eduaction and Research (BMBF) programme
- GIraFFE: Dairy Goat Co-operative (DGC), Hamilton, New Zealand
- Hope: AAK BV Netherlands
- LifeCycle: EU Horizon 2020 project, grant agreement n. 733206
- ProthEUs:
- ToMI: Nestec Ltd., Ave, Nestlé 55 CH-1800 Vevey, Switzerland
Koletzko Lab
AG Berthold Koletzko
Dr. von Hauner Children’s Hospital
Lindwurmstr. 4, D-80337 Munich
Email: office.koletzko@med.uni-muenchen.de
Subgroups Email address:
ChiFHA: kind.chifha@med.uni-muenchen.de