Koletzko Lab
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Subgroups
- Child and Family Health Academy (ChiFHA)
- Child Health Foundation (CHF)
- MS-Core Facility
- Clinical Study
Prof. Dr. med. Berthold Koletzko
✉ Berthold.Koletzko@med.uni-muenchen.de
☎ +49-89-4400-52826
- Child and Family Health Academy (ChiFHA)
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Four subgroups of Prof. Koletzko consist of Child and Familiy Health Academy (ChiFHA), Child Health Foundation, MS-Core Facility and Clinical Study.
Child and Family Health Academy (ChiFHA)Child and Family Health Academy imparts high-quality, up-to-date, evidence-based education and training covering a wide range of health-related topics focusing focusing on the well-being of children and families. Our target audience is healthcare professionals, researchers, and new investigators around the world, who are aiming to improve healthcare services whilst fostering their careers through Continuing Medical Education (CME) & Continuing Professional Development (CPD).
ChiFHA’s vision is to be a worldwide-recognized benchmark Academy in the area of child and family health. Through accessible online and blended learning formats, we break cost, time and space barriers, for maximum outreach. Our end-goal is to support and improve worldwide health from early life stages through capacity building and empowerment of international healthcare professionals and researchers. Through global and regional academies and programmes, learners can select their course based on their topics of interest and specific content tailored to the requirements of each region.
The global programmes comprise projects ENeA Global, MOOC, Early Nutrition Specialist (ENS); while the regional programmes comprise projects EU funded projects ImpENSA and ENeA SEA, EATS Indonesia, EndObesity, ENeA Hebammenwissen, and Intereg CD Skills.
More information about ChiFHA at https://chifha.org
Child Health FoundationThe Child Health Foundation (CHF) is actively involved in the healthy development of children and adolescents. It informs the public on key health issues and, in collaboration with partners and specialists, explains preventive strategies that can be implemented in day care, kindergartens and schools.
The operative implementation of the foundation’s work is based on three pillars:
• Prevention with programs applicable in practice
• Competence in the field of health prevention
• Effective public education
Health promotion and prevention are especially important for children. Nowadays pediatric and adolescent medicine can successfully treat a broad variety of illnesses. Yet, health promotion and the prophylaxis of illnesses still have a long way to go and remain key priorities. Overall, the main goal of the CHF is to ensure the best possible start in life for children.
More information about the Child Health Foundation at https://www.kindergesundheit.de/
MS-Core FacilityThe MS-Core Facility in the Dr. von Hauner Children´s Hospital performs targeted LC-MS/MS based analysis of biological samples such as plasma, serum, milk and tissue from humans as well as animals from small research studies (e.g. elephant milk, cat plasma and mouse tissue) to medium and large clinical cohort studies (e.g. HOPE, RisCoin, CORKUM, ToMi and CHOP). The MS-Core Facility team works in close collaboration with in-house LMU-Klinikum research groups as well as research groups from other international universities and companies to facilitate correct sample collection, processing, storage and shipment. Hence, we offer and provide support already during the planning and writing stage of a clinical study, which includes stablishing a suitable budget plan as well as setting up material transfer agreements. In addition, we also offer help and assistance for statistical data evaluation of LC-MS generated metabolome and lipidome data sets.
Our metabolomics platform analysis includes amino acids (20 proteinogenic AAs plus Cit and Orn), organic acids and keto-acids from the TCA-cycle (15), acyl-carnitins (60) and glycerophosphocholines (PCaa, PCae, LPCa, LPCe and SM; a = acyl and e = ether; 320). Besides that, we also perform method development for sample preparation and quantitative analysis of free short, medium and long chain fatty acids, endocannabinoids, bile acids and lipid hydrolysis, among others. Presently we are also establishing the Biocrates MxP Quant 500XL Kit in our lab. For further information, please visit our webpage:
https://www.ccrc-hauner.de/technology-platforms/mass-spectrometry/d990e77de89f6bfb
Nutritional StudiesThe nutritional study team conducts research on nutrition in early life and its long-term health consequences. Currently, the following studies and projects are ongoing or have been recently finished:
Studies:
- CHOP (Childhood Obesity Project): A long term follow-up of a cohort that included an intervention with infant formula with differing protein content during the first year of life in five European countries. Multiple study visits with anthropometric measurements including body composition, blood and urine samples, metablomics and lipidomics, genom- and epigenomwide association studies (GWAS and EWAS), physical activity and psychometric outcomes have been included. Currently, the follow-up in 20 years old adults is performed.
- GIRAFFE-study (Goat infant formula feeding and eczema study): Intervention study to examine the effect of goat and cow milk consumption on the development of allergic diseases. The study is conducted in 10 Polish and Spanish centers with about 2100 children. More information: Giraffe Study – Goat Infant Formula Feeding and Eczema study (giraffe-study.com) ; https://bmjopen.bmj.com/content/13/4/e070533
- HOPE: Observational study with the aims to characterize human milk lipids with bioactive potential and the impact of maternal diabetes mellitus on human milk during the first four month of life. More information: HOPE-Studie | LMU Klinikum (lmu-klinikum.de)
- ToMI (Toddler milk intervention trial): Trial with about 1600 children looking at the effect of protein intake during the second year of life on growth, development and metabolism. Currently, the follow-up with six years is performed. Further information: Tomi Studie | LMU Klinikum (lmu-klinikum.de) ; https://bmjopen.bmj.com/content/11/12/e048290
- ProtEUs: Intervention study to examine the effects of an infant formula with an optimized amino acid composition on growth and development during the first year of life. The trial has been terminated in 2023 with the last visit at 6 years of age.
Projects:
- BiomarKid: Biomarker signatures of diet, physical activity and sleep in children and youth. JPL/BMBF funded project. More information: Research Framework (healthydietforhealthylife.eu)
- EndObesity: Prevention of unhealthy weight gain and obesity during crucial phases throughout the lifespan. JPL/BMBF funded project. More information : EndObesity - Strategien zur Verhinderung von Übergewicht und Adipositas bei Kindern in den ersten 1000 Lebenstagen (gesundheitsforschung-bmbf.de)
- LifeCycle: Horizon 2020 project completed. The project aimed to establish an Europe- wide network of early-life cohort studies. More information: Home - LifeCycle (lifecycle-project.eu); EU Child Cohort Network
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Child and Family Health Academy (ChiFHA) Team
Dr. Shweta Feher
Associate Director ChiFHA
Scientific director: ENS & ENeA Hebammenwissen; Programme Head: EATS Indonesia, MOOC, ENeA Global; Programme Coordinator: ImpENSA, CD Skills, ENeA SEA
✉ shweta.feher@med.uni-muenchen.de
☎ 089- 4400- 52816
Rungrawee Loipimai
ChiFHA Communications Manager
Project Manager ImpENSA & ENeA SEA
✉ rungrawee.loipimai@med.uni-muenchen.de
☎ 089- 4400- 52832
Marina Sanchez
ChiFHA Scientific Content Manager
Project Manager, EATS INA
✉ marina.sanchez@med.uni-muenchen.de
☎ 089- 4400- 53104
Tania Duque
Scientific Content Developer & Reviewer
✉ tania.duque@med.uni-muenchen.de
☎ 089- 4400- 54165
Martina Forro
ChiFHA Administration
Admin. Project Manager, CD Skills & EATS INA
✉ martina.forro@med.uni-muenchen.de
☎ 089- 4400- 57929
Erin Baudendistel-Happ
ChiFHA Technical Manager
Programme Manager, ENS
✉ erin.baudendistelhapp@med.uni-muenchen.de
☎ 089- 4400- 57896
Jelica Gencel
Scientific Content Developer & Reviewer
Project Manager, ENeA Global, MOOC & EndObesity
✉ jelica.gencel@med.uni-muenchen.de
☎ 089- 4400- 52981
Clinical Study Team
Mohammed El Sharkawy
Research associate/ PhD Student
Nadja Antl
Research associate
On maternity leave
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Christiane Haesner-Stricker
Study nurse
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MS-Core Facility Team
Dr. Jeannie Horak
Laboratory Head of the MS-Core Facility
✉ Jeannie.Horak@med.uni-muenchen.de
☎ 089- 4400- 57971
Room: D1.05
Dr. Nilay Can
Biostatistician and Bioinformatician of the MS-Core Facility
✉ Nilay.Can@med.uni-muenchen.de
☎ 089- 4400- 53153
Room: D1.05
Stephanie Winterstetter
Chemical Technical Assistant (CTA)
✉ StephanieKatrin.Winterstetter@med.uni-muenchen.de
Room: D1.02
Dr. Hans Demmelmair
Clinical Project Coordinator of the MS-Core Facility
✉ hans.demmelmair@med.uni-muenchen.de
☎ 089- 4400- 53692
Room: G1.16
Dr. Bernadeta Patro-Golab
Humboldt Research Fellow
(Metabolomics Data Evaluation)
✉ Bernadeta.Patrogolab@med.uni-muenchen.de
Karin Kantke
Pharmaceutical Technical Assistant (PTA)
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Andrea Vielhauer
Medical Technical Assistant (MTA)
✉ Andrea.Vielhauer@med.uni-muenchen.de
☎ 089- 4400- 53167
Room: D1.16
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ChiFHA
Global e-Learning in Early Nutrition and Lifestyle for International Healthcare Professionals: Design and Evaluation of the Early Nutrition Specialist Programme (ENS), Brands, B., Tran, N. N., Baudendistel-Happ, E., Sanchez-Garcia, M., Fischer, M. R., & Koletzko, B. (2021). Nutrients, 13(3), 775. https://doi.org/10.3390/nu13030775
Early Nutrition eAcademy Southeast Asia e-Learning for Enhancing Knowledge on Nutrition during the First 1000 Days of Life, Brands B., Chomtho S., Suthutvoravut U., Chiong Meng Boey C., Tang, S. F., Godfrey, K. M., Koletzko, B., & For The ENeA Sea Project Group (2020). Nutrients, 12(6), 1817. https://doi.org/10.3390/nu12061817
Nutrition During Pregnancy, Lactation and Early Childhood and its Implications for Maternal and Long-Term Child Health: The Early Nutrition Project Recommendations, Koletzko, B., Godfrey, K. M., Poston, L., Szajewska, H., van Goudoever, J. B., de Waard, M., Brands, B., Grivell, R. M., Deussen, A. R., Dodd, J. M., Patro-Golab, B., Zalewski, B. M., & EarlyNutrition Project Systematic Review Group (2019). Annals of nutrition & metabolism, 74(2), 93–106. https://doi.org/10.1159/000496471
Long-Term Health Impact of Early Nutrition: The Power of Programming, Koletzko, B., Brands, B., Grote, V., Kirchberg, F. F., Prell, C., Rzehak, P., Uhl, O., Weber, M., & Early Nutrition Programming Project (2017). Annals of nutrition & metabolism, 70(3), 161–169. https://doi.org/10.1159/000477781
Curricula customization with the readerbench Framework, Gutu-Robu G., Trausan-Matu S., Dascalu M., Carabas M., Elisei A., Nistor N., Choi S., Spoerl R., & Koletzko B. (2018) Roceanu I., Beligan D., Ciolan L. & Stefan I. (eds.) In eLearning challenges and new horizons: Proceedings of the 14th International Scientific Conference "eLearning and Software for Education". National Defence University Publishing House. pp. 385-392. doi:10.12753/2066-026X-18-123
How growth due to infant nutrition influences obesity and later disease risk, Brands, B., Demmelmair, H., Koletzko, B., & EarlyNutrition Project (2014). Acta paediatrica (Oslo, Norway : 1992), 103(6), 578–585. https://doi.org/10.1111/apa.12593
Optimal nutrition in lactating women and its effect on later health of offspring: A systematic review of current evidence and recommendations (EarlyNutrition project), de Waard, M., Brands, B., Kouwenhoven, S. M. P., Lerma, J. C., Crespo-Escobar, P., Koletzko, B., Zalewski, B. M., & van Goudoever, J. B. (2017). Critical reviews in food science and nutrition, 57(18), 4003–4016. https://doi.org/10.1080/10408398.2016.1158149
Early nutrition programming of long-term health, Koletzko, B., Brands, B., Poston, L., Godfrey, K., Demmelmair, H., & Early Nutrition Project (2012). The Proceedings of the Nutrition Society, 71(3), 371–378. https://doi.org/10.1017/S0029665112000596
The Early Nutrition Programming Project (EARNEST): 5 y of successful multidisciplinary collaborative research, Koletzko, B., Brands, B., Demmelmair, H., & Early Nutrition Programming Project (2011). The American journal of clinical nutrition, 94(6 Suppl), 1749S–1753S. https://doi.org/10.3945/ajcn.110.000471
European Childhood Obesity Trial Study Group (2013). Early influences of nutrition on postnatal growth, Koletzko, B., Beyer, J., Brands, B., Demmelmair, H., Grote, V., Haile, G., Gruszfeld, D., Rzehak, P., Socha, P., Weber, M., & Nestle Nutrition Institute workshop series, 71, 11–27. https://doi.org/10.1159/000342533
The Power of Programming and the EarlyNutrition project: opportunities for health promotion by nutrition during the first thousand days of life and beyond, Koletzko, B., Brands, B., Chourdakis, M., Cramer, S., Grote, V., Hellmuth, C., Kirchberg, F., Prell, C., Rzehak, P., Uhl, O., & Weber, M. (2014). Annals of nutrition & metabolism, 64(3-4), 187–196. https://doi.org/10.1159/000365017
The effect of diet on the physical and mental development of children: views of parents and teachers in four European countries, Egan, B., Gage, H., Williams, P., Brands, B., Györei, E., López-Robles, J. C., Campoy, C., Decsi, T., Koletzko, B., & Raats, M. (2019). The British journal of nutrition, 122(s1), S31–S39. https://doi.org/10.1017/S000711451500032X
Frühkindliche Ernährung und späteres Adipositasrisiko. Hinweise auf frühe metabolische Programmierung [Infant feeding practice and later obesity risk. Indications for early metabolic programming], Koletzko, B., Schiess, S., Brands, B., Haile, G., Demmelmair, H., von Kries, R., & Grote, V. (2010). Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 53(7), 666–673. https://doi.org/10.1007/s00103-010-1079-y
Views of parents in four European countries about the effect of food on the mental performance of primary school children, Gage, H., Egan, B., Williams, P., Györei, E., Brands, B., López-Robles, J. C., Campoy, C., Koletzko, B., Decsi, T., & Raats, M. (2014). European journal of clinical nutrition, 68(1), 32–37. https://doi.org/10.1038/ejcn.2013.214
MS-Core FacilityClinical Study -
ChiFHAMS-Core Facility
- BiomarKID
- RisCoin (Covid immunization study),
- COVID-19 CORKUM (metabolomics and lipidomics study, steroidomics project)
- Childhood-Obesity Programme (CHOP, RCT with long term follow up)
- Toddler Milk Intervention Trial (TOMI, NCT02907502)
Effect of milk protein intake in young children on early growth and obesity risk
- NutriPROGRAM
Multi-omics approach using 1H-NMR and LC-MS metabolomics combined with epigenetic data sets of several cohort studies (CHOP, Generation-R, Candle, etc.) for epigenetic pathway analysis
- Thailand Breast Milk Project
Normalization of milk volume produced by the mother and intake by the infant, using [2H]-labelled water; analysis of serum, cord blood, milk, Fe and Zn
- Supplementation of breastfed LBWI in Indonesia
Pilot study completed, RCT ongoing
- ERC Advanced Grant Pathophysiology of Primary Aldosteronism (PAPA)
Nutritional Studies- BiomarKid: DLR Projektträger, Förderkennzeichen 01EA2203A; European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL, BiomarKid) and German Federal Ministry of Education and Research (BMBF) programme
- CHOP: Nestec Ltd., Ave, Nestlé 55 CH-1800 Vevey, Switzerland
- EndObesity: DLR Projektträger, Förderkennzeichen 01EA2101; European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL, EndObesity) and German Federal Ministry of Eduaction and Research (BMBF) programme
- GIRAFFE: Dairy Goat Co-operative (DGC), Hamilton, New Zealand - Sophie Gallier
- Hope: AAK BV Netherlands
- LifeCycle: EU Horizon 2020 project, grant agreement n. 733206
- ProthEUs:
- ToMI: Nestec Ltd., Ave, Nestlé 55 CH-1800 Vevey, Switzerland
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Koletzko Lab
AG Berthold Koletzko
Dr. von Hauner Children’s Hospital
Lindwurmstr. 4, D-80337 Munich
Email: office.koletzko@med.uni-muenchen.de
Subgroups Email address:
ChiFHA: kind.chifha@med.uni-muenchen.de