Schaub Lab
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Research topics
Childhood asthma and allergy
- Early life immune regulation
- Environment and Tolerance development
- Allergy prevention
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The main research interest of her group is to identify immunological mechanisms in the development of allergic diseases in childhood. Ongoing projects in several national and international birth cohort studies include the influences of regulatory immune responses of the infant immune system in the development of allergic diseases in childhood. The laboratory of Prof. Schaub has a strong interest in the effect of early maternal and environmental factors on the development of the fetal and infant immune system and subsequently the allergic phenotype.
Deutsches Zentrum für Lungenforschung (DZL, BMBF)In terms of disease incidence and mortality, lung diseases are ranked second in the world and are directly or indirectly responsible for every fifth death. The annual cost of lung diseases amounts to 102 billion euros alone for Western Europe. It is expected that the number of patients and thus also the costs will continue to rise in the coming years. To date, there are no cures for most respiratory dieases- just symptomatic treatments.
Asthma is the most prevalent chronic respiratory disease in childhood and is also very common in adults. Although the clinical manifestations of asthma in children and adults are rather uniform with wheezing, shortness of breath and cough, population-based clinical and genetic studies suggest that asthma is not one disease, but many. Thus, a single “one-size-fits-all” treatment approach is unlikely to work to tackle this important health problem. In order to design personalized treatment approaches for asthma patients, there is urgent need to elucidate the mechanisms underlying the various types of asthma. The decoding of such mechanisms and their translation to the individual patient is the aim of the Disease Area Asthma and Allergy of the DZL and their clinical flagship project ALLIANCE (All Age Asthma Cohort).
CHAMP - CHildhood Allergy and tolerance: bioMarkers and Predictors (BMBF project)The CHAMP Consortium investigates the determinants of different allergic diseases (food allergy, atopic dermatitis, asthma, hay fever) across the whole pediatric age range. Particular attention will be given to factors determining primary tolerance (no onset of disease) and acquired tolerance (remission of existing disease). We will identify clinically relevant biomarkers predicting early onset, progression and remission. As main results, we aim to define a molecular allergy score early in life predicting subsequent allergy risk, to identify predictors of natural tolerance of food allergy and to examine underlying mechanisms in murine models of allergy development with focus on early tolerance induction. We aim to predict mild versus severe allergic diseases, to identify relevant biomarkers and to predict remission of asthma and hay fever. Furthermore/ we will analyse HRQoL of patients and quality of life (QoL) of their parents across different allergic diseases, different disease stages and various age groups.
This consortium has the unique opportunity to assess the development and remission of childhood allergies at all stages of childhood immune and organ development. Adding new insight to the puzzle of early onset, natural tolerance and remission of different allergic diseases from birth to adolescence will lay the ground for future development of preventive strategies. In the long term, this shall contribute to open up novel avenues for therapeutic options. This clearly will make an impact on the life of our patients and their families.
Role of pro- and anti-inflammatory NF-κB and MAPK signaling of innate dendritic cells during asthma development in childhood and its modulation through farm environmental exposure (DFG)This project aims to disentangle the role of inflammatory regulation (NF-κB and MAPK signalling) during immune maturation in childhood asthma development and its protection via environmental stimulation. Having blood samples from several time points of two birth cohorts and one cross-sectional cohort of children, which are at risk for asthma or protected from asthma offers a unique opportunity to examine immune mechanisms of asthma development. Two central mechanisms of interest are pro- and anti-inflammatory pathways during immune maturation and how these can be modulated in order to prevent the development of childhood asthma.
Multinational study on rural environmental protection for childhood asthma – a central role for dendritic and regulatory B-cells during immune maturation (DFG)Multinational study on rural environmental protection for childhood asthma – a central role for dendritic and regulatory B-cells during immune maturation
This multinational study aims to identify central mechanisms of environmental protection for childhood asthma in both Europe and China. By assessing dendritic cells (DC) and regulatory B-cells (Breg) during immune maturation, this project aims to disentangle novel central regulatory hubs which contribute to asthma protection via two strong asthma-protective environments.
The unique chance of having consecutive blood samples of children at several ages of an European birth cohort from the strongest asthma-protective environment, namely farming, available and in parallel recruiting Chinese children from urban HongKong (and Guangzhou) with high asthma prevalence and rural Conghua with low prevalence at age 6 years allows the comparison of asthma-protective mechanisms across Europe and China.
Components of distinct rural environments confer asthma protection in childhood via A20-mediated immune effects in dendritic cells on regulatory T cells (DFG)This project aims to disentangle distinct protective immune regulatory mechanisms of A20-mediated effects of dendritic (DC) and regulatory T cells (Tregs) for childhood asthma by stimulation of blood cells with compounds of environmentally distinct areas. The unique natural exposure to two environments strongly protecting from childhood asthma, i.e. farms in Europe and rural areas in China offers the great opportunity to assess underlying immune mechanisms which are distinct from each other.
As A20 (anti-inflammatory) and inflammasome regulation have been shown differentially expressed following different dust stimulation, we will identify the specific role of A20 and inflammasome regulation following environmental exposure with different dusts in cell lines, and isolated cells. We will disentangle specific asthma-protective immune mechanisms via A20-mediated effects of DCs on Tregs through exposure to distinct rural environmental dust in healthy and asthmatic children. We will unravel the effect of environmental dust extracts from different environmental areas (Germany, Finland, China) on T reg-function, methylation, acetylation (FOXP3 promoter), and mTOR signalling. We aim to identify signalling of A20 regulation in DCs and inflammasome activation. We aim to investigate the effect of A20-regulation in DCs and inflammasome activation on Treg-mediated suppression. Finally, in a proof-of-principle experiment, we will assess the effects of dust stimulation on A20-regulation in DCs, inflammasome and Treg regulation in children protected from asthma in comparison to asthmatic children.
PASTURE/EFRAIM: Protection against Allergy: Study in Rural Environments (EU)The EFRAIM project prospectively investigated protective factors in early life influencing the development of allergies in birth cohorts conducted in rural areas in five European countries. Detailed information on a great variety of environmental exposures was collected and large biobanks have been established. The mechanisms mediating these protective exposures such as the maturation of immune responses, gut colonisation, the mucosal barrier function and the genetic and epigenetic factors interacting with the environmental exposures were investigated.
Currently, allergic diseases can be managed effectively but not cured. The knowledge about protective exposures early in life can, however, be turned into the development of preventive strategies. The EFRAIM project was expected to produce ground-breaking new insights on protective agents and their mechanisms that can be used to prevent the further development of allergies.
In 2019, the 16 year follow-up of the cohort is starting.
Paulina/Paulchen study (birth cohorts)Paulina/Paulchen are two prospective birth cohorts that have been recruited since 2008 and 2009 in Munich and in a rural area in the Munich area. Here, the risk and protection against asthma in the populations can be examined. The aim is to investigate the influence of early risk factors or protective factors on the immune system and the development of asthma and allergies in childhood. This implements, among other things, the study of genetics, epigenetics and gene expression. The children are now older than 16 years and are continuously tracked for the development of asthma and allergies.
Clara/Claus studyThe Clara/Claus study is a large cross-sectional study on bronchial asthma in Munich. The aim of the study is to investigate immune regulation in the development of bronchial asthma in childhood. A detailed questionnaire is collected, the children are clinically characterized in detail and the immune system is examined at various levels (genetics, epigenetics, gene regulation, cytokines) and the microbiome is recorded. The children will be followed up after 1 and 3 years. The results should help to define different asthma phenotypes, to better understand their pathophysiology and to identify new mechanisms of disease development.
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Claudia Beerweiler, M. Sc.
Doctoral Researcher (PhD Track)
✉ Claudia.Beerweiler@med.uni-muenchen.de
☎ 089 4400-57895
Room: AU.06/07
Francesco Foppiano Florez Estrada, M. Sc.
Doctoral Researcher (PhD track)
✉ Francesco.Foppiano@med.uni-muenchen.de
☎ 089 4400-57351
Room: Wal 23.501
Alexander Neuner, Cand. med.
Doctoral Researcher (MD track)
✉ Alexander.Neuner@med.uni-muenchen.de
Room: AU.06/07
Dr. rer. nat. Kathrin Urner.
Research Study Coordinator
✉ Kathrin.Urner@med.uni-muenchen.de
☎ 089 4400-57343
Room: Wal 23.503
Sarah Geiger, Cand. med.
Doctoral Researcher (MD track)
✉ Sarah.Geiger@med.uni-muenchen.de
Room: AU.06/07
Kristina Laubhahn, PhD
Post Doctoral Researcher
✉ Kristina.Laubhahn@med.uni-muenchen.de
☎ 089 4400-57353
Room: Wal.503
Juliane Rinne, Cand. med.
Doctoral Researcher (MD track)
✉ Juliane.Rinne@med.uni-muenchen.de
Room: AU.06/07
Clinical /Translational Study Team
Dr. med. Meike Köhler
Pediatrician, Allergologist, Pneumologist
✉ Meike.koehler@med.uni-muenchen.de
☎ 089 4400 5 7878
Dr. med. Franziska Sattler
Research Physician
✉ Franziska.Sattler@med.uni-muenchen.de
☎ 089 4400 5 7878
Dr. med. Nicole Maison
Pediatrician, Allergologist
✉ Nicole.maison@med.uni-muenchen.de
☎ 089 4400 5 7878
Dr. med. Kathrin Kalkbrenner
Clinician Scientist
Alumni
Alina KämpfJana Eckert Fabian HoppmannElisabeth Klucker Tatjana Nicklas Elisabeth Nowak Katharina Rehbach Michael Salvermoser Kim SchultisGabriele SuslkiJohanna Theodorou -
Selected Publications
1. Gorlanova O, Oller H, Marten A, Müller L, Laine-Carmelli J, Decrue F, Salem Y, Vienneau D, Hoogh K, Gisler A, Usemann J, Korten I, Yammine S, Nahum U, Künstle N, Sinues P, Schulzke S, Latzin P, Fuchs O, Röösli M, Schaub B, Frey U; BILD study group. Ambient prenatal air pollution exposure is associated with low cord blood IL-17a in infants. Pediatr Allergy Immunol. 2023 Jan;34(1):e13902. doi: 10.1111/pai.13902. PMID: 36705042.
2. Yang Z, Chen Z, Lin X, Yao S, Xian M, Ning X, Fu W, Jiang M, Li N, Xiao X, Feng M, Lian Z, Yang W, Ren X, Zheng Z, Zhao J, Wei N, Lu W, Roponen M, Schaub B, Wong GWK, Su Z, Wang C, Li J. Rural environment reduces allergic inflammation by modulating the gut microbiota. Gut Microbes. 2022 Jan-Dec;14(1):2125733. doi: 10.1080/19490976.2022.2125733. PMID: 36193874.
3. H Raifer, AR Schulz, J Theodorou, AJ Romero-Olmedo, A Böck, WBertrams, BT Schmeck, HR Chung, M Lohoff, H Chang, B Schaub#, H. Mei#, M Huber# Mass cytometry-based identification of a unique T-cell signature in childhood allergic asthma. Allergy. 2022 Jan;77(1):313-316. doi: 10.1111/all.15110. PMID: 34564874.
4. Xing Y, Wang MH, Leung TF, Wong CK, Roponen M, Schaub B, Li J, Wong GWK. Poultry exposure and environmental protection against asthma in rural children. Allergy. 2022 May 9. doi: 10.1111/all.15365.
5. Laubhahn K, Böck A, Zeber K, Unterschemmann S, Kunze S, Schedel M, Schaub B. 17q12-21 risk-variants influence cord blood immune regulation and multitrigger-wheeze. Pediatr Allergy Immunol. 2022 Feb;33(2):e13721. doi: 10.1111/pai.13721. PMID: 34919286.
6. Illi S, Depner M, Pfefferle PI, Renz H, Roduit C, Taft DH, Kalanetra KM, Mills DA, Farquharson FM, Louis P, Schmausser-Hechfellner E, Divaret-Chauveau A, Lauener R, Karvonen AM, Pekkanen J, Kirjavainen PV, Roponen M, Riedler J, Kabesch M, Schaub B, von Mutius E; PASTURE Study Group. Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers. Am J Respir Crit Care Med. 2022 Mar 15;205(6):641-650. doi: 10.1164/rccm.202106-1458OC. PMID: 34919021.
7. S Pechlivanis, M Depner, PV Kirjavainen, C Roduit, M Täubel, R Frei, C Skevaki, A Hose, E Schmausser-Hechfellner, MJ Ege, B Schaub, A Divaret-Chauveau, R Lauener, AM Karvonen, J Pekkanen, J Riedler, S Illi, E von Mutius and the PASTURE Study Group. Continuous rather than solely early farm exposure protect from hay fever development. J Allergy Clin Immunol Pract. 2022 Nov 7:S2213-2198(22)01137-0. doi: 10.1016/j.jaip.2022.10.035. Online ahead of print. PMID: 36356926.
8. Kopp MV, Muche-Borowski C, Abou-Dakn M, Ahrens B, Beyer K, Blümchen K, Bubel P, Chaker A, Cremer M, Ensenauer R, Gerstlauer M, Gieler U, Hübner IM, Horak F, Klimek L, Koletzko BV, Koletzko S, Lau S, Lob-Corzilius T, Nemat K, Peters EMJ, Pizzulli A, Reese I, Rolinck-Werninghaus C, Rouw E, Schaub B, Schmidt S, Steiß JO, Striegel AK, Szépfalusi Z, Schlembach D, Spindler T, Taube C, Trendelenburg V, Treudler R, Umpfenbach U, Vogelberg C, Wagenmann M, Weißenborn A, Werfel T, Worm M, Sitter H, Hamelmann E. S3 guideline Allergy Prevention. Allergol Select. 2022 Mar 4;6:61-97. doi: 10.5414/ALX02303E. eCollection 2022. PMID: 35274076.
9. J Theodorou, E Nowak, A Böck, M Salvermoser, K Zeber, P Kulig, MS Tsang, CK Wong, G W.K. Wong, M Roponen, J Kumbrink, F Alhamdan, F Michel, H Garn, V Tosevski, B Schaub. MAPK signaling in childhood asthma development and environment-mediated protection. Pediatr Allergy Immunol. 2022 Jan;33(1):e13657. doi: 10.1111/pai.13657. Epub 2021 Sep 14. PMID: 34455626.
10. N. Maison, J Omony, S Illi, D Thiele, C Skevaki, AM Dittrich, Thomas Bahmer, K F Rabe, M Weckmann, C Happle, B Schaub, H Renz, G Hansen, M Volkmar Kopp, E v Mutius, R Grychtol, and the ALLIANCE Study Group. T2-high asthma phenotypes across life span. Eur Respir J. 2022 Feb 24:2102288. doi: 10.1183/13993003.02288-2021.
11. Eckert J, J Kahle, A Böck, K Zeber, K Urner, W Greiner, S Kreimeier, K Beyer, JDobbertin-Welsch, E Hamelmann, I Gellhaus, C Schorlemer, M Kabesch, P Kheiroddin, E von Mutius, M Depner, D Walter, G Hansen, S DeStefano, S Schnadt, B Schaub. CHildhood Allergy and tolerance: bioMarkers and Predictors (CHAMP) and quality of life. Pediatr Allergy Immunol. 2021 Aug 16. doi: 10.1111/pai.13652. PMID: 34396594.
12. Salvermoser M*, Zeber K*, Boeck A, Klucker E, Schaub B. Childhood allergies: novel endotyping by cytokines, validated through sensitization profiles and clinical characteristics. Clin Exp Allergy. 2021 Mar 1. doi: 10.1111/cea.13858. Online ahead of print. PMID: 33650157.
13. Weckmann M, Bahmer T, Bülow Sand JM, Rank Rønnow S, Pech M, Vermeulen C, Faiz A, Leeming DJ, Karsdal MA, Lunding L, Oliver BGG, Wegmann M, Ulrich-Merzenich G, Juergens UR, Duhn J, Laumonnier Y, Danov O, Sewald K, Zissler U, Jonker M, König I, Hansen G, von Mutius E, Fuchs O, Dittrich AM, Schaub B, Happle C, Rabe KF, van de Berge M, Burgess JK, Kopp M; ALLIANCE Study Group as part of the German Centre for Lung Research (DZL). COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy. Eur Respir J. 2021 Jul 29:2003969. doi: 10.1183/13993003.03969-2020. Online ahead of print. PMID: 34326188.
14. Depner, M, Taft, DH, Kirjavainen, PV, Kalanetra, KM, Karvonen, AM, Peschel, …PASTURE study group, Hyvärinen A, Illi S. Pfefferle PI, Schaub B., …MJ Ege, Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma, Nat Med. 2020 Nov 2. doi: 10.1038/s41591-020-1095-x. Online ahead of print.Nat Med. 2020. PMID: 33139948
15. Laubhahn K, Schaub B. Paediatric severe asthma: a need for novel innate molecular phenotypes. Eur Respir J 2019; 54: 1901459 [https://doi.org/10.1183/13993003.01459-2019]. Editorial.
16. J. Krusche, M. Twardziok, K. Rehbach, A. Böck, M. Tsang, P.C. Schröder, Y Xing, J. Riedler, JC Dalphin, J. Pekkanen, R. Lauener, M. Roponen, J. Li, C.K. Wong, G. Wong, B. Schaub and the PASTURE study group. TNF-α–induced protein 3 is a key player in childhood asthma development and environment-mediated protection. J Allergy Clin Immunol. 2019 Dec;144(6):1684-1696.e12. doi: 10.1016/j.jaci.2019.07.029. PMID: 31381928.
17. N Krautenbacher, N Flach, A Böck, K Laubhahn, M Laimighofer, FJ Theis, DP Ankerst, C Fuchs, B Schaub. A strategy for high‐dimensional multivariable analysis classifies childhood asthma phenotypes from genetic, immunological, and environmental factors. Allergy. 2019 Jul;74(7):1364-1373. doi: 10.1111/all.13745. Epub 2019 Mar 31. PMID: 30737985.
18. PV Kirjavainen, AM Karvonen, RI Adams, M Täubel, M Roponen, P Tuoresmäki, G Loss, B Jayaprakash, M Depner, MJ Ege, H Renz, PI Pfefferle, B Schaub, R Lauener, A Hyvärinen, R Knight, DJJ Heederik, E von Mutius and J Pekkanen. Farm-like indoor microbiota in non-farm homes protects children from asthma development. Nat. Medicine, June 2019, 17. Doi: 10.1038/s41591-019-0469-4.
19. L Campos Carrascosa, M Klein, Y Kitagawa, C Lückel, F Marini, A König, A Guralnik, H Raifer, S Hagner-Benes, D Rädler, A Böck, C Kang, M Lohoff, H Garn, B Schaub, F Berberich-Siebelt, S Sakaguchi, T Bopp and M Huber. Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4. Nat Commun. 2017 May 12;8:15366. doi: 10.1038/ncomms15366. PMID: 28497800.
Current Reviews
1. Foppiano F, Schaub B. Childhood asthma phenotypes and endotypes: a glance into the mosaic. Mol Cell Pediatr. 2023 Aug 30;10(1):9. doi: 10.1186/s40348-023-00159-1. PMID: 37646843 Review.
2. Laubhahn K, Phelan KJ, Jackson DJ, Altman MC, Schaub B. What Have Mechanistic Studies Taught Us About Childhood Asthma? J Allergy Clin Immunol Pract. 2023 Mar;11(3):684-692. doi: 10.1016/j.jaip.2023.01.004. Epub 2023 Jan 14. PMID: 36649800 Review.
3. Beerweiler CC, Masanetz RK, Schaub B. Asthma and allergic diseases: Cross talk of immune system and environmental factors. Eur J Immunol. 2023 Jun;53(6):e2249981. doi: 10.1002/eji.202249981. Epub 2023 Feb 1. PMID: 36645095 Review.
4. Cabanillas B, Murdaca G, Guemari A, Torres MJ, Azkur AK, Aksoy E, Vitte J, de Las Vecillas L, Giovannini M, Fernández-Santamaria R, Castagnoli R, Orsi A, Amato R, Giberti I, Català A, Ambrozej D, Schaub B, Tramper-Stranders GA, Novak N, Nadeau KC, Agache I, Akdis M, Akdis CA. A compilation answering 50 questions on monkeypox virus and the current monkeypox outbreak. Allergy. 2023 Mar;78(3):639-662. doi: 10.1111/all.15633. Epub 2023 Jan 11. PMID: 36587287 Review.
5. Wahn U, Lau S, Eigenmann P, Melen E, Krauss-Etschmann S, Lex C, Matricardi P, Schaub B, Halken S, Ege M, Jackson D, Hamelmann E, Szépfalusi Z, Garcia AN, von Mutius E. Early priming of asthma and respiratory allergies: Future aspects of prevention: A statement by the European Forum for Education and Research in Allergy and Airway Disease (EUFOREA) and the EAACI-Clemens von Pirquet Foundation. Early priming of asthma and respiratory allergies: Future aspects of prevention. Pediatr Allergy Immunol. 2022 Apr;33(4):e13773. doi: 10.1111/pai.13773.
6. Albrecht M, Schaub B, Gilles S, Köhl J, Altrichter S, Voehringer D, Spillner E, Ehlers M, Jönsson F, Loser K, Mayer JU, Rösner LM, Möbs C, Heine G, Pfützner W. Current research and unmet needs in allergy and immunology in Germany: report presented by the DGfI and DGAKI task force AK Allergy & Immunology, Invited review, Eur J Immunol. 2022 Jun;52(6):851-855. doi: 10.1002/eji.202270065.
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Wandertag Neureuth Juli 2024
EAACI Conference 2024: Caroline and Francesco presenting their posters
B2Run 2024
Team allergology of the university children´s hospital (Dr. von Haunerschen Kinderspital) at the B2run of LMU Klinikum 2024: Nicole and Elisabeth
Kick-Off DZKJ 2024
Prof. Dr. Markus M. Lerch, Ärztlicher Direktor des LMU Klinikums with Prof. Dr. Bianca Schaub, together with the new ambassador of the Munich Child Health Alliance, Felix Neureuther.
PhD Graduation Kristina Laubhahn 2023
EAACI 2023: Scientific presentations of Caroline, Claudia and Francesco
Hiking day 2022: Maisinger Schlucht
Hiking day 2022: Maisinger Schlucht
Hiking day 2019 am Riederstein
Lab challenge im Hauner, 2022
Labor farewell party for Tatjana, 2020
Birthday wishes, 2021
B2Run des LMU Klinikum: Sarah, Jana und Johanna, 2019.
Stay abroad(fellowship) in Hongkong 2019: Katharina Rehbach, Miranda Tsang, Yuhan Xing
Bayerische Labor-Tradition, Oktoberfest 2019
Hiking day 2017 Auer Alm
EAACI Conference presentation Kristina Laubhahn
EAACI Conference presentation Johanna Krusche
Rural chicken and farm exposure
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Oral abstract price winner 2024
Francesco Foppiano won the prize for the best oral presentation at EAACI 2024
DZL 4.0 BMBF-project started in January 20244th DZL period has started in January 2024 (-2027):
The Disease Area Asthma and allergy with the Munich CPC-M scientific coordinators Bianca Schaub and Nicole Maison (as young academy) together with Susanne Krauss-Etschman (Borstel) has the following major goals:
For the ALL Age Asthma Cohort (ALLIANCE):
1. to identify mechanisms resulting in early loss of function and asthma progression and compare findings across DAs;
2. to continue the follow-up of successfully recruited ALLIANCE patients with a focus on the ‘comorbidome’ and aging;
3. to increasingly integrate patient perspective into ALLIANCE research;
For basic research:
4. to address trained/mistrained immunity for asthma development & protection,
5. to study microbes providing a health- or asthma-promoting environment,
6. to investigate ung function loss and resilience,
7. to foster biomarker development for diagnostic improvement, and
8. to identify synthetic and natural compounds for prevention and therapy.
News from ERS (European Respiratory Society) 2023Prof. Dr. med. Bianca Schaub has won the prestigious research prize of the ERS (European Respiratory Society), the "ERS Mid-Career Gold Medal in Asthma Award" 2023.
The "ERS Mid-Career Gold Medal Program" awards various research prizes to outstanding researchers with excellent performance in the respective fields.
This high-ranking scientific award for her outstanding success to date is also given to Prof. Schaub in recognition of her potential for future excellent research in the field of bronchial asthma. The prize will be awarded at this year's ERS Congress 2023 in Milan and is endowed with €40,000 (sponsor: AstraZeneca).
Prof. Schaub holds a DFG Heisenberg professorship at the university children's clinic of the LMU Munich/LMU Klinikum. She heads the allergology department at the Dr. von Hauner Children's Hospital and heads the Laboratory for Allergy/Immunology at the CCRC (Comprehensive Childhood Research Centre) in Munich.
Johannes Wenner Prize 2023Nicole Maison1,2
1Abteilung für Asthma und Allergie, Dr von Haunersches Kinderspital, LMU Klinikum, München
2Institut für Asthma- und Allergie Prävention (IAP), Helmholtz Zentrum München
Effects of increased rhinovirus circulation on the development of asthma in early childhood
In the multicenter longitudinal asthma study “AllAgeAsthmaCohort” (ALLIANCE), the “T2-high” asthma phenotype was characterized and identified from infancy to adulthood using readily available biomarkers. It is characterized by the onset of the disease in early childhood, persistence into adulthood and a high need for therapy. “T2 high” asthma is associated with viral respiratory infection caused by respiratory syncytial virus (RSV) and subtypes A and C of rhinovirus (RV). Infections with RSV and RV have increased dramatically as a result of the corona-related hygiene measures. The aim of the research project is to identify possible risk variants of the rhinovirus by sequencing rhinovirus isolates from nose/throat swabs in patients with a recent rhinovirus infection. In this project, based on the ALLIANCE cohort and the PROTECT Study (Pediatric RhinOvirus DeTEction and Correlation With Early Asthma), more detailed immune mechanisms underlying the association of RV infections and “T2 high” asthma will be investigated.
Commission of Friedrich-Bauer-Stiftung approved project funding of 7,100 EUR (2023)The research project "Establishment of a real-time metabolic analysis method to investigate trained immunity in the development of childhood bronchial asthma" by Dr. rer. nat. Andreas Böck and Claudia Beerweiler (M.Sc.) aims to establish real-time metabolic analysis in primary cells as a pilot project in the Schaub lab. The overall goal is to establish a methodological basis to investigate the role of trained immunity in childhood and adolescence using metabolic analyses. In addition, we will investigate whether the phenomenon of trained immunity is associated with the asthma protective effect observed in farming environments.Allergy Center CertificationAllergy center certified as a Comprehensive Allergy Center
More information to follow:
Election as DA AA coordinator at the German Lung CenterThe 11th DZL annual meeting took place in Fürstenfeldbruck from June 14th to 16th. It was organized by the DZL Munich location (CPC-M). More than 550 researchers gathered here to exchange knowledge and promote collaboration in the field of lung research.
A great success for the DZL Munich location was the election of Prof. Dr. med Schaub and Dr. Nicole Maison as scientific coordinator and DZL Academy Fellow coordinator of the disease area “AA”.
https://www.cpc-munich.de/en/newsevents/news/news/article/31081.html
Panel discussion at the LMU female academic network F.A.M.E.Heisenberg Professorship successfully extendedProf. Dr. med. Bianca Schaub was awarded a professorship of LMU Munich (Heisenberg Professorship of DFG, german research foundation) with the title “Environment and development of immunological tolerance” („Umwelt und immunologische Toleranzentwicklung“) with the focus on the development of allergic diseases. This was now succesfully prolonged. The Heisenberg Professorship, named after the physicist, promotes excellent scientists following criteria of scientific excellence
New Publication: TNF-α–induced protein 3 is a key player in childhood asthma development and environment-mediated protectionNew Publication by Johanna Krusche, MonikaTwardziok, Katharin Rehbach...Bianca Schaub in Journal of Allergy and Clinical Immunology about TNF-α–induced protein (link).
Johanna Krusche awarded Junior Research Award of DGAKIJohanna Krusche (Phd Student at the group of Prof. Dr. med. Bianca Schaub) has been awarded the 2019 Junior Research Award of DGAKI (Nachwuchsförderpreis).
This price is awarded to young scientists for excellent work on the topic of allergy and clinical immunology and supports young scientists.
It is endowed with 5.000 € and donated from Sanofi-Aventis Deutschland GmbH.
Kristina Laubhahn awarded oral abstract prize at EAACI 2019Kristina Laubhahn (Phd Student at the group of Prof. Dr. med. Bianca Schaub) has been awarded an oral abstract prize for an outstanding oral abstract presentation at the EAACI 2019 conference.
The title was: Pathway analysis - genetic and immunological influences of gene polymorphisms in 17q21 locus on childhood wheeze.Bianca Schaub awarded Heisenberg ProfessorshipProf. Dr. med. Bianca Schaub was awarded a professorship of LMU Munich (Heisenberg Professorship of DFG, german research foundation) with the title “Environment and development of immunological tolerance” („Umwelt und immunologische Toleranzentwicklung“) with the focus on the development of allergic diseases. The Heisenberg Professorship, named after the physicist, promotes excellent scientists following criteria of scientific excellence.
Prof. Schaub, Consultant and Deputy Head of the Department of Allergology in the University Children´s Hospital of Munich, Dr. von Hauner Children's Hospital, examines the role of early life immune maturation for the development of allergic disease since numerous years.
The focus of this Heisenberg Professorship comprises the assessment of the environment and the development of immunological tolerance from birth until allergy development in childhood. This will be investigated in several birth and cross-sectional cohorts of children with risk or protection from allergies. To characterize molecular mechanisms of the different phenotypes, a number of methods of „computational medicine“ will be used. The identification of biomarkers for specific therapy strategies for childhood allergic diseases will contribute to develop future prevention studies and clinicial studies with novel biologicals.
Doctoral student awarded LMU research award 2018The LMU Research Award for excellent students was awarded to the project „Identification of novel immunological mechanisms for childhood asthma“ of the research group of Prof. Dr. Bianca Schaub, Dr. von Hauner University Children´s Hospital Munich. The students (MD/PhD) are: Bettina Anselm, Hedwig Grella, Simone Hüttner, Johanna Krusche, Alexander Neuner, Tatjana Nicklas, Elisabeth Nowak, Katharina Rehbach, Kim Schultis, Julia Schüßling, Elif Turan, Vanessa Vogelsang.
The project investigates successfully which immunological mechanismus are critical during the development of childhood asthma. One focus was how environment-mediated mechanisms lead to protection from asthma. The extent of the work and the originality are both impressive: the students have performed excellent work starting from the recruitment of the children, establishing experimental protocols for small children until performing the protocols and the statistical analysis. They could achieve groundbreaking findings, which have already been published in numerous manuscripts. These findings are critical for the prevention of childhood asthma and offer novel opportunities for future research projects.
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Schaub Lab
Dr. von Hauner Children's Hospital
Hospital of the Ludwig-Maximilians-University (LMU) Munich
Lindwurmstr. 4
80337 Munich, Germany
Visiting Address /Lab
CCRC Research Building (Kubus)
Lindwurmstraße 2a
80337 Munich, Germany
Room AU.06/07
Phone: +49 (0)89 - 4400 – 52857 (Office)
Phone: +49 (0)89 - 4400 – 57781 (Lab)
Fax: +49 (0)89 - 4400 – 54764
Email: Bianca.schaub@med.uni-muenchen.de
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DZL Study
The Munich DZL team of the ALLIANCE cohort at KUM (and ZAUM)
Project:
In terms of disease incidence and mortality, lung diseases are ranked second in the world and are directly or indirectly responsible for every fifth death. The annual cost of lung diseases amounts to 102 billion euros alone for Western Europe. It is expected that the number of patients and thus also the costs will continue to rise in the coming years. To date, there are no cures for most respiratory dieases- just symptomatic treatments.
Asthma is the most prevalent chronic respiratory disease in childhood and is also very common in adults. Although the clinical manifestations of asthma in children and adults are rather uniform with wheezing, shortness of breath and cough, population-based clinical and genetic studies suggest that asthma is not one disease, but many. Thus, a single “one-size-fits-all” treatment approach is unlikely to work to tackle this important health problem. In order to design personalized treatment approaches for asthma patients, there is urgent need to elucidate the mechanisms underlying the various types of asthma. The decoding of such mechanisms and their translation to the individual patient is the aim of the Disease Area Asthma and Allergy of the DZL and their clinical flagship project ALLIANCE (All Age Asthma Cohort).
Consortium
The DZL Consortiums consists of 5 sites in Germany: Sites - Deutsches Zentrum für Lungenforschung (dzl.de)
The ALLIANCE cohort represents the All Age Asthma Cohort of the DZL:
ALLIANCE (All Age Asthma Cohort) - Deutsches Zentrum für Lungenforschung (dzl.de)
The Munich DZL team of the ALLIANCE cohort at KUM has the following team members (alphabetical order):
Sarah Andoni, laboratory technician (MTA)
Mira Bürk, M.A.
Sibylle Contento, Clinician Scientist
Prof. Dr. Markus Ege, MD, MA, MPH, Professor of clinical-respiratory epidemiology
Dr. Alexander Hose, Statistician
Nicola Korherr, Study Nurse
Lena Ullemeyer, M Sc, PhD student
Lena Lagally, M Sc, PhD student
Dr. Nicole Maison, Clinician Scientist
Katharina Stahmer, Study Assistant
Esther Zeitlmann, Study Coordinator
Contact:
DZL study
Coordinator: Prof. Dr. med. Bianca Schaub
Study assistant: Eva Wakolbinger
Dr. von Hauner Children´s Hospital, University Hospital LMU Munich
Lindwurmstr. 4, 80337 Munich,
Email: eva.wakolbinger@med.uni-muenchen.de
Website: ALLIANCE (All Age Asthma Cohort) - Deutsches Zentrum für Lungenforschung (dzl.de)